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Application of MG53/MG53 mutant-containing composition in preparation of inflammatory bowel disease drug

A technology of inflammatory bowel disease and composition, which is applied in the field of prevention and treatment of inflammatory bowel disease, can solve problems such as poor curative effect, and achieve the effect of meeting long-term treatment needs, quick results, and good promotion and application prospects

Pending Publication Date: 2018-09-04
MUDANJIANG YOUBO PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the evaluation of DSS-induced acute ulcerative colitis and Crohn's disease models, it is a common practice to administer drugs while modeling. After 7 days of modeling, the marketed drugs will not see obvious callback effects. Experts in the industry also recognize this A modeling method, from another perspective to explain the poor efficacy of marketed drugs

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  • Application of MG53/MG53 mutant-containing composition in preparation of inflammatory bowel disease drug
  • Application of MG53/MG53 mutant-containing composition in preparation of inflammatory bowel disease drug
  • Application of MG53/MG53 mutant-containing composition in preparation of inflammatory bowel disease drug

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Embodiment Construction

[0089] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0090] Application of a composition containing MG53 in the preparation of drugs for preventing and treating inflammatory bowel disease.

[0091] Preferably, MG53 is any one of the following six types, or any one of them and one of the corresponding agonists and / or antagonists.

[0092] 1) comprising MG53 polypeptide;

[0093] 2) comprising a nucleic acid encoding a MG53 polypeptide;

[0094] 3) including MG53 polypeptide, nucleic acid encoding MG53 polypepti...

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Abstract

The invention provides application of an MG53 / MG53 mutant-containing composition in preparation of a drug for preventing and treating the inflammatory bowel disease. The mutant is non-polar amino acidalanine mutated from a serine site in the Coiled-coil structural domain of MG53. A mouse ulcerative colitis model is built through induction of dextran sulfate sodium (DSS); 5-aminosalicylic acid (5-ASA) is used as a positive drug for contrast; evaluation of a disease activity index (DAI), the length of a colon, a weight change and pathological changes of a colon tissue verifies that the composition has an obvious inhibition effect on the DSS-induced colitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a composition containing MG53 and a composition containing MG53 mutants in the prevention and treatment of inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a group of chronic nonspecific intestinal inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC). In 1956, Chinese scholar Professor Wen Shiyu published the earliest IBD-related articles in China: "Analysis and Discussion of 23 Cases of Ulcerative Colitis" and "Report of a Case of Crohn's Disease of Gastroduodenum and Jejunum". In 1978, the diagnostic criteria for UC was put forward in the first national meeting of digestive diseases, which started the exploration journey of basic and clinical research of IBD in China. In the past 20 years, the number of IBD cases in my country has also increased rapidly, which has greatly stimulated the attenti...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K38/17A61P1/04A61P1/00A61K31/7105A61K33/30
CPCA61K31/7105A61K33/30A61K38/1709A61K45/06A61P1/00A61P1/04A61K2300/00
Inventor 慎东
Owner MUDANJIANG YOUBO PHARMA CO LTD
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