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A kind of combination medicine for treating acne and its application

A drug and acne technology, which is applied in the field of combined drugs for the treatment of acne, and can solve problems such as drug resistance and teratogenicity

Active Publication Date: 2021-05-07
四川省中医药科学院中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine for the treatment of acne mainly adopts the following methods for etiology: ① Inhibition of local inflammation: oral and topical antibiotics such as tetracycline, minocycline, metronidazole, etc.; ② anti-androgen: oral estrogen, progesterone, Spironolactone, etc.; ③Inhibit sebaceous gland secretion, improve hyperkeratosis of hair follicles: such as using retinoic acid, zinc sulfate, etc.; the above treatments have certain curative effects, but Western medicine treatment is prone to drug resistance and many side effects, such as mouth Dryness, peeling lips, dry and itchy skin, gastrointestinal reactions, etc., and teratogenicity will occur when women of childbearing age take it

Method used

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  • A kind of combination medicine for treating acne and its application
  • A kind of combination medicine for treating acne and its application
  • A kind of combination medicine for treating acne and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, preparation of oral product of the present invention

[0025] 1. Recipe: 15g cinnamon, 15g dried ginger, 30g coix seed, 3g angelica, 30g kudzu root, 20g medlar, 30g poria cocos, 15g bellflower, 10g amomum.

[0026] 2. Preparation method: Weigh the raw material according to the formula, add 10-15 times of water and soak for 15 minutes for pretreatment; decoct and extract 2-4 times, each time for 15-30min, filter the filtrate after each decoction, mix all The filtrate is left to stand for 20 hours, and the supernatant is concentrated to a thick paste with a relative density of 1.15-1.3; the temperature of the air inlet is 180-200°C, and the temperature of the outlet air is 90-100°C, and the extract is obtained by spray drying.

[0027] Add 900g of the above extract to 900g of maltodextrin, 200g of maltose powder, and 240g of 90% ethanol, put it in a swing granulator and pass through a 20-mesh sieve for granulation, and dry it at 50°C for 8 hours. After dryin...

Embodiment 2

[0029] Embodiment 2, preparation of oral product of the present invention

[0030] 1. Recipe: 30g cinnamon, 27g dried ginger, 50g coix seed, 10g angelica, 60g kudzu root, 40g medlar, 45g poria cocos, 36g bellflower, 24g amomum.

[0031] 2. Preparation method: Weigh the raw material according to the formula, add 10-15 times of water and soak for 15 minutes for pretreatment; decoct and extract 2-4 times, each time for 15-30min, filter the filtrate after each decoction, mix all The filtrate is left to stand for 20 hours, and the supernatant is concentrated to a thick paste with a relative density of 1.15-1.3; the temperature of the air inlet is 180-200°C, and the temperature of the outlet air is 90-100°C, and the extract is obtained by spray drying.

[0032] The above 450g extract was mixed with 450g maltodextrin, 100g maltose powder and 120g 90% ethanol, placed in a swing granulator and passed through a 20-mesh sieve for granulation, and dried at 50°C for 8 hours. Granules, get...

Embodiment 3

[0034] Embodiment 3, preparation of oral product of the present invention

[0035] 1. Recipe: 5g cinnamon, 10g dried ginger, 15g coix seed, 1g angelica, 10g kudzu root, 10g medlar, 15g poria cocos, 9g bellflower, 6g amomum.

[0036] 2. Preparation method: Weigh the raw material according to the formula, add 10-15 times of water and soak for 15 minutes for pretreatment; decoct and extract 2-4 times, each time for 15-30min, filter the filtrate after each decoction, mix all The filtrate was allowed to stand still for 20 hours, and the supernatant was concentrated to a thick paste with a relative density of 1.15-1.3; the thick paste was dried in an oven at 60-65°C for 16 hours, and dried until it could not flow; then placed in a decompression dryer (65°C, -0.1MPa) and dried under reduced pressure for 8 hours, and thoroughly dried to obtain the extract. The above 450g extract was mixed with 450g maltodextrin, 100g maltose powder, and 120g 90% ethanol to granulate, dried, and divid...

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Abstract

The invention discloses a combined drug for treating acne and its application. The combined drug is composed of an internal product and an external product; , Poria cocos, platycodon grandiflorum; said external product is made of angelica, skullcap, forsythia, saponins, prunella vulgaris, rhubarb, coix seed, honeysuckle, salvia miltiorrhiza, red peony root, tribulus terrestris, sealwort, ganoderma, notoginseng, red It is prepared from flowers and peach kernels. The results of clinical experiments show that there are significant differences in acne symptoms before and after the product of the present invention is used, indicating that the product combination of the present invention has the functions of dispelling wind and clearing heat, detoxifying and dispelling stagnation, promoting blood circulation and removing blood stasis, and has obvious curative effects on acne treatment and skin lesion recovery. And the method of internal and external treatment can shorten the acne treatment cycle and enhance the acne treatment effect.

Description

technical field [0001] The invention relates to a combined medicine for treating acne and its application. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. From newborns to adults, almost people of all ages can suffer from it. The clinical manifestations are acne, papules, pustules, nodules, etc. Characterized by skin lesions. The prevalence of acne in all regions of the world ranges from 70% to 87%. [0003] At present, Western medicine for the treatment of acne mainly adopts the following methods for etiology: ① Inhibition of local inflammation: oral and topical antibiotics such as tetracycline, minocycline, metronidazole, etc.; ② anti-androgen: oral estrogen, progesterone, Spironolactone, etc.; ③Inhibit sebaceous gland secretion, improve hyperkeratosis of hair follicles: such as using retinoic acid, zinc sulfate, etc.; the above treatments have certain curative effects, but Western medicine treatment is prone to drug r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/8994A61P17/10A61K8/9794A61K8/9789A61K8/9728A61Q19/00A23L33/00
CPCA23V2002/00A61K9/0014A61K9/0053A61K36/074A61K36/076A61K36/185A61K36/232A61K36/258A61K36/286A61K36/346A61K36/355A61K36/483A61K36/488A61K36/536A61K36/537A61K36/539A61K36/54A61K36/634A61K36/65A61K36/708A61K36/71A61K36/736A61K36/815A61K36/8969A61K36/8994A61K36/9064A61K36/9068A61Q19/00A23L33/00A61K8/9728A61K8/9789A61K8/9794A61P17/10A61K2300/00A23V2200/318
Inventor 黄蜀罗霞陈纯涛许晓燕张颜李芳代庆娇江南万娟甘宗容
Owner 四川省中医药科学院中医研究所
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