Near-infrared non-invasive detection method of human tissue hemoglobin concentration index

Abstract

The invention discloses a near-infrared non-invasive detection method of human hemoglobin concentration index. Firstly, a photoelectric receiving tube is placed on three positions on the surface of human tissue to be tested, and at the same position at one end of an extension line connecting the three photoelectric receiving tubes, Set three light-emitting diodes LS with different light-emitting wavelengths, then detect the scattered light intensity received by each photoelectric receiving tube, and calculate its optical density OD, and according to OD(k,λ i ) to calculate the relative change of optical density ΔOD(λ i ), and finally according to the measured ΔOD(λ i ), calculate the hemoglobin concentration index tHI of the tissue to be tested. The invention adopts a three-wavelength light source and three detectors, which is beneficial to improve the detection accuracy and eliminate the influence of going out to cover the tissue; the light source adopts a light-emitting diode, so that the measured tissue hemoglobin concentration index is stable and reliable; the measured tissue hemoglobin concentration The index is proportional to the total concentration of hemoglobin in the tissue and can reflect the percentage change of the concentration of hemoglobin in the tissue to be tested.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a near-infrared noninvasive detection method of human hemoglobin concentration index. Background technique [0002] Hemoglobin concentration refers to the amount of hemoglobin contained in a unit volume of blood. Hemoglobin, also known as hemoglobin, is a pigment-binding protein that is the main component of red blood cells. It can combine with oxygen and transport oxygen and carbon dioxide. The concentration of hemoglobin and the change of hemoglobin concentration are important basis for prompting the status of human body and human organs. The non-invasive detection of the hemoglobin concentration index of human tissue can obtain the percentage change of hemoglobin concentration in human tissue, which is beneficial to real-time evaluation of the blood filling level of the tissue to be tested. [0003] The patent documents of publication numbers US005632273A, CN1...

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Problems solved by technology

[0003] The patent documents of publication numbers US005632273A, CN1333011A, CN1331953A and CN1544947A propose a detection method based on the revised Lambert-Beer law, but this method has limited consideration of the strong scattering characteristics of near-infrared light in human tissue, and can only obtain the tissue to be measured The change range of the hemoglobin concentration in the tissue relative to its measured initial value cannot be obtained; when the hemoglobin concentration in the tissue decreases to the same extent, the lower the initial value of the concentration, the more severe the ischemia and hypoxia, which cannot be determined by the hemoglobin concentration in the tissue Reflected by the magnitude of the change, but can be reflected by the percentage of its change

In addition, the patent document with the publication number CN1911172 discloses a method for detecting the absolute amount of hemoglobin concentration in human tissue, but it is only applicable to detection occasions where the outer covering tissue is relatively thin, and when detecting adult cerebral cortex and skeletal muscle, Due to the thick outer covering tissue, the detection error of this method is relatively large

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