Near-infrared non-invasive detection method for concentration index of human tissue hemoglobin

Abstract

The invention discloses a near-infrared non-invasive detection method for the concentration index of human hemoglobin. The near-infrared non-invasive detection method comprises the following steps offirstly respectively placing a photoelectric receiving tube on three positions of the surface of a human tissue to be detected, arranging three light-emitting diodes LS with different light-emitting wavelengths at the same positions of the extending lines of the connecting lines of the three photoelectric receiving tubes; then detecting the scattering light intensity received by all the photoelectric receiving tubes, calculating the optical density OD, and calculating the relative change amount delta OD (lambda i) of the optical density when the wavelength is lambda i according to the OD (k, lambda i); finally, calculating the concentration index tHI of the hemoglobin concentration index of the tissue to be detected according to the calculated delta OD(lambda i). The near-infrared non-invasive detection method disclosed by the invention has the beneficial effects that by adoption of three-wavelength light sources and three detectors, the benefit for improving the detection accuracy andeliminating the influence of the outer-layer covering tissue is achieved; the light-emitting diodes are adopted as the light sources, so that the detected the hemoglobin concentration index of the tissue is reliable; the detected the hemoglobin concentration index of the tissue is in direct proportion to the total concentration of the hemoglobin in the tissue, and the percentage of the concentration change of the hemoglobin in the tissue to be detected can be reflected.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a near-infrared noninvasive detection method of human hemoglobin concentration index. Background technique [0002] Hemoglobin concentration refers to the amount of hemoglobin contained in a unit volume of blood. Hemoglobin, also known as hemoglobin, is a pigment-binding protein that is the main component of red blood cells. It can combine with oxygen and transport oxygen and carbon dioxide. The concentration of hemoglobin and the change of hemoglobin concentration are important basis for prompting the status of human body and human organs. The non-invasive detection of the hemoglobin concentration index of human tissue can obtain the percentage change of hemoglobin concentration in human tissue, which is beneficial to real-time evaluation of the blood filling level of the tissue to be tested. [0003] The patent documents of publication numbers US005632273A, CN1...

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Problems solved by technology

[0003] The patent documents of publication numbers US005632273A, CN1333011A, CN1331953A and CN1544947A propose a detection method based on the revised Lambert-Beer law, but this method has limited consideration of the strong scattering characteristics of near-infrared light in human tissue, and can only obtain the tissue to be measured The change range of the hemoglobin concentration in the tissue relative to its measured initial value cannot be obtained; when the hemoglobin concentration in the tissue decreases to the same extent, the lower the initial value of the concentration, the more severe the ischemia and hypoxia, which cannot be determined by the hemoglobin concentration in the tissue Reflected by the magnitude of the change, but can be reflected by the percentage of its change

In addition, the patent document with the publication number CN1911172 discloses a method for detecting the absolute amount of hemoglobin concentration in human tissue, but it is only applicable to detection occasions where the outer covering tissue is relatively thin, and when detecting adult cerebral cortex and skeletal muscle, Due to the thick outer covering tissue, the detection error of this method is relatively large

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