Preparation method of traditional Chinese medicine extract, traditional Chinese medicine extract and granular preparation

Abstract

The invention relates to a preparation method of traditional Chinese medicine extract, the traditional Chinese medicine extract and a granular preparation. The preparation method of the traditional Chinese medicine extract comprises the following steps: step 1, decompressing and concentrating a traditional Chinese medicine extracting solution at 70 DEG C to 80 DEG C until the relative density is 1.25 to 1.33g / cm<3>, so as to obtain an extract primary product; step 2, carrying out circulating colloid milling on the extract primary product obtained by step 1 at 70 DEG C to 80 DEG C; while carrying out colloid milling, adding an anti-condensation and anti-caking auxiliary agent; finishing the adding of the anti-condensation and anti-caking auxiliary agent when the mass content of the anti-condensation and anti-caking auxiliary agent in the extract primary product is about 0.5 percent; after continually carrying out the colloid milling for 15 to 20 minutes, collecting extract, so as to obtain the traditional Chinese medicine extract. According to the traditional Chinese medicine extract, the layering, caking and condensation problems of the traditional Chinese medicine extract are solved, and the dissolubility of the extract is improved, so that the color and luster of a prepared granular finished product are consistent, the content of effective components is uniform and the yieldof the finished products is improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese veterinary medicines, and in particular relates to a preparation method of traditional Chinese medicine extracts, traditional Chinese medicine extracts and granule preparations. Background technique [0002] Traditional Chinese veterinary drug granules such as Maxing Shigan Granules and Banqing Granules are widely used in animal breeding. According to the requirements of veterinary drug quality standards, the production of traditional Chinese veterinary drug granules usually adopts wet granulation process. The main steps are: 1) decocting and extracting medicinal materials to obtain an extract; 2) concentrating the extract to obtain an extract, which is then temporarily stored in a cold storage; 3) adding auxiliary materials to the extract to make a soft material; 4) Granulate, dry, and sieve to obtain finished granules. Among them, the extract is used as an intermediate of wet granulation of g...

AI Technical Summary

Problems solved by technology

[0003] 1. During the concentration process, the extract close to the tank wall is heated earlier than the extract in the middle, that is, the extract at the edge is concentrated faster than the extract in the middle, which will lead to uneven density distribution of the extract, and over-concentrated part of the extract Viscosity increases, thus forming a small lump phenomenon; even dry scab phenomenon, that is, the paste pot phenomenon; so in the process of collecting the cream, there is a phenomenon of small lumps, and the extract with excessive density solidifies into a solid state , resulting in inhomogeneous properties of the finished granules

[0004] 2. During the storage process of the extract in cold storage, stratification, agglomeration and solidification often occur, which makes it more difficult for the extract to enter the granulator from the storage tank during the wet granulation process, and even solidifies into a solid state. The color of the finished granules is not uniform, resulting in unqualified properties of the finished granules

[0005] 3. The solubility of the extract is not complete, especially after storage in cold storage, the solubility of the extract is even worse, which makes the solubility of the finished granules not up to the standard, which affects the efficacy of the medicine

[0006] 4. Low yield of extract

Images