Oral care composition and application thereof

[0050] Example 1

[0051] An oral care composition, comprising the following components by weight: 0.5 parts of zinc citrate, 4.5 parts of zinc glycinate, 0.2 parts of sodium monofluorophosphate, 1.6 parts of sodium fluorosilicate, 1 part of strontium lactate, and 5 parts of potassium citrate and 1 part sodium bicarbonate.

[0052] Example 2

[0053] An oral care composition, comprising the following components by weight: 0.1 part of zinc citrate, 0.9 part of zinc glycinate, 0.05 part of sodium monofluorophosphate, 0.15 part of sodium fluorosilicate, 0.1 part of strontium lactate, and 1 part of potassium citrate and 0.5 part sodium bicarbonate.

[0061] Experimental example 1

[0062] 1. Spot removal experiment

[0063] 50 maxillary isolated central incisors were collected in the department of stomatology of a certain hospital. After ultrasonic cleaning, they were immersed in 50% tea water respectively. After soaking for one week under the same conditions, the collected stained isolated teeth were subjected to colorimetry. The percentage index of the tooth area occupied by the stain was recorded, and 30 isolated teeth with an index of 45% were obtained.

[0064] Divide 30 isolated teeth into 6 groups, and use Examples 1-2, Comparative Examples 3-5 and commercially available toothpastes to treat the isolated teeth. Take 1.0 g of the teeth at 6:00 am and 7:00 pm every day. Toothpaste, use a soft-bristled toothbrush, and clean for 2 minutes.

[0065] Table 1. Percentage index of stained area on isolated teeth

[0066] group

[0067] As shown in Table 1: record the percentage index of the tooth tissue area occupied by stains within 15 days, and comprehensively analyze the percentage data of the tooth area occupied by stains before the experiment to determine the comparison of the stain removal effects of Example 1 and Example 2 Obviously, at the same time, the stain removal effect of Example 1 was the best, and after the experiment, it was found that the isolated teeth of Examples 1 and 2 were significantly whiter than the teeth of the other groups. Therefore, the oral care composition of the present invention has the effect of removing plaque and whitening teeth.

[0068] 2. Dental caries incidence test

[0069] Select 70 SD rats, half male and female, weighing about 55g, and divide them into 7 groups on average. Put Streptococcus mutans and Lactobacillus into TSB enrichment solution for culture (culture density is 50/mL), culture for 24 hours and then Dip the enrichment solution with a cotton swab and apply it to the alveolus of the lower molars of the rats (inoculated once a week), feed them with sucrose, and raise them for six months. Use cotton swabs to dip the toothpastes of Examples 1 to 2, Comparative Examples 1 to 3 and commercially available ones and apply them to the alveoli of the lower molars of SD rats. Occurrence (regardless of the specific number of caries, as long as there is caries, it is regarded as caries), the incidence of caries at three months and six months is investigated, and the results are shown in Table 2.

[0070] Table 2. Test results of dental caries incidence

[0071] group

[0072] It can be seen from Table 2 that the toothpastes of Examples 1 and 2 can effectively prevent the occurrence of dental caries, indicating that the toothpastes have good lasting bacteriostatic effect and good cleaning power. Comparative example 3 was compounded with zinc citrate and sodium fluorosilicate, and comparative example 4 was compounded with zinc glycinate and sodium monofluorophosphate. The experiment found that the incidence of dental caries in comparison examples 3 and 4 was higher than that in comparison example 5 and the commercially available group. low, indicating that the antibacterial effect of the toothpastes of Comparative Examples 3 and 4 is better than that of Comparative Example 3 and the implementation group.

[0073] 3. Tooth hypersensitivity effect

[0074] 300 patients with sensitive toothache were selected for a blind trial, 50 people in each group. After brushing their teeth for 1 minute, they rinsed their mouths with cold water and stimulated with airflow.

[0075] The judgment criteria are:

[0076] Markedly effective: no pain (significant effect);

[0077] Effective: there is discomfort but basically no pain (effective);

[0078] Normal: Painful but tolerable (with general effect);

[0079] Ineffective: Painful and unbearable (no obvious effect).

[0080] Effective rate=(marked effect+effective+general)/total number of cases×100%.

[0081] Table 3. Tooth hypersensitivity test results

[0082]

[0083] As can be seen from Table 3, the oral care composition of the present invention has a significant analgesic and desensitization treatment effect.