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Neuregulin for the treatment and/or prevention of tumors of the nervous system

A technology of neurotonin and nervous system, applied in the field of peptides, can solve problems such as inability to obtain targeted therapy for diseases

Pending Publication Date: 2018-11-09
LEIBNIZ INST FUR ALTERNSFORSCHUNG FRITZ LIPMANN INST E V FLI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, disease-targeted therapies specific to NF2-related organisms are still unavailable

Method used

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  • Neuregulin for the treatment and/or prevention of tumors of the nervous system
  • Neuregulin for the treatment and/or prevention of tumors of the nervous system
  • Neuregulin for the treatment and/or prevention of tumors of the nervous system

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Experimental program
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Embodiment Construction

[0050] In Table 1, the nucleotide sequences of preferred embodiments of neurotonins are listed.

[0051] Table 1: Nucleotide sequences of preferred neuregulin proteins

[0052]

[0053]

[0054]

[0055]

[0056] Thus in one embodiment the invention includes nucleic acid molecules as described herein selected from the group consisting of:

[0057] a) a nucleic acid molecule comprising or consisting of: an EGF-like domain encoding a neuregulin protein, preferably the nucleotide sequence of the EGF-like domain according to the sequence of SEQ ID NO 1-4,

[0058] B) a nucleic acid molecule comprising or consisting of: an EGF-like domain encoding a neuregulin protein, preferably a nucleotide sequence according to the EGF-like domain of the SEQ ID NO 1-4 sequence, wherein the nucleic acid molecule has a length of 50 between 500 nucleic acids, preferably between 100 and 300 nucleic acids, most preferably between 150 and 220 nucleic acids, wherein the surrounding sequenc...

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Abstract

The invention relates to a polypeptide, wherein said polypeptide comprises or consists of an EGF-like domain of a neuregulin protein. The invention more over relates to a nucleic acid encoding for said polypeptide, a gene therapy vector comprising said nucleic acid and genetically modified cells expressing said polypeptide. The invention relates to the medical use of said polypeptide, said nucleicacid, said gene therapy vector or said cell for the treatment of tumours of the nervous system, in particular for the treatment of tumours of the cranial or peripheral nerves, tumours associated withneurofibromatosis, schwannomas, neurofibromas and malignant nerve sheath tumours.

Description

[0001] describe [0002] The present invention relates to a polypeptide, wherein said polypeptide comprises or consists of the following: EGF-like domain of neuregulin protein. The present invention relates to nucleic acids encoding said polypeptides, gene therapy vectors comprising said nucleic acids, and genetically modified cells expressing said polypeptides. The present invention relates to the medical use of said polypeptide, said nucleic acid, said gene therapy vector and / or said cells for treating nervous system tumors, especially for treating cranial nerve or peripheral nerve tumors, neurofibromatosis-related Tumors, Schwann cell tumors, neurofibromas, and malignant schwannomas. Background technique [0003] Neurofibromatosis (NF) is a genetic disorder that results in a medical condition affecting the nervous system, skin, bones, and muscles and is often manifested by the presence of multiple soft nodules, neurofibromas, and associated hyperpigmented macules . The d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P35/00
CPCA61K38/18A61P35/00
Inventor 亚历山大·舒尔茨海伦·莫里森
Owner LEIBNIZ INST FUR ALTERNSFORSCHUNG FRITZ LIPMANN INST E V FLI
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