The present invention discloses an inhibitive effect of Na+—K+-
ATPase caused by a compound selected from the group consisting of
magnesium lithospermate B (MLB), isomer,
prodrug, derivative, pharmaceutically acceptable salt, and a composition thereof. In this invention, the variations of Na+—K+-
ATPase activity were monitored with increasing MLB concentrations, and the result shows the Na+—K+
ATPase activity is repressed by MLB. An outcome of the
inhibitory effect, the function of cellular
sodium /
potassium exchanger is reduced and cellular
calcium ion concentration is increased. The cerebral
ischemia test exhibited MLB provides an effective repression of
cell infarct. That is, the MLB is useful for inhibiting the function of cellular Na+—K+ pump, and further brings the utility for
cardiac stimulation,
diuretic enhancement,
heart failure curing, anti-anoxia, neurocyte
apoptosis protection, apoplexy prevention and treatment, and so on.