Application of PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products

An inflammatory bowel disease and inhibitor technology, applied in the application field of medicine and health care products, can solve problems such as less research, achieve the effect of inhibiting immune response, increasing SOD activity, controlling occurrence and development

Inactive Publication Date: 2018-11-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are few domestic and foreign studies on PDE9A in the intestinal tract

Method used

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  • Application of PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products
  • Application of PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products
  • Application of PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The experiment selected C57 female mice with a body weight of about 20 g. All mice were randomly divided into control group (control group), model group (DSS group), sulfasalazine group (AS group), and low-dose group (PF3 group). , medium dose group (PF10 group), high dose group (PF30 group), a total of 6 groups, 5 in each group.

[0042] The control group was fed with deionized water, and the other 5 groups were fed with 3% DSS solution.

[0043] During the period, the sulfasalazine group was intragastrically administered daily at a dose of 0.5g / kg, and the PF-04447943 low-dose group, medium-dose group, and high-dose group were intragastrically administered daily at doses of 3mg / kg, 10mg / kg, and 30mg / kg, respectively. The body weight of the mice and the water bottle were weighed and recorded every day. On the 8th day, the mice were killed under deep anesthesia, and the colon, mesenteric lymph nodes, spleen and anus of the mice were collected, and the length of the col...

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Abstract

The invention relates to application of a PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products, and relates to the field of medicines. The PDE9A inhibitor can improve mucus secretion of a mucous membrane in the intestinal tract with inflammatory bowel diseases, reducesecretion of TNF- alpha, IL-6, IL-17 and IL-12 / IL-23 pro-inflammatory factors, inhibit DC cell differentiation and migration, increase the proportion of Foxp3+Treg cells and promote the movement of CD4+CD25+Treg cells from the spleen and mesenteric lymph nodes into the colon, thereby inhibiting the inflammatory reaction of the intestinal tract and controlling occurrence and development of the diseases. When applied to drugs for preventing and treating inflammatory bowel diseases, the PDE9A inhibitor can effectively prevent, alleviate and treat the inflammatory bowel diseases; and furthermore,the health care products taking the PDE9A inhibitor as an active component can condition the intestinal tracts of patients suffering from inflammatory bowel diseases so as to control occurrence and development of the inflammatory bowel diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of PDE9A inhibitors in the preparation of products for increasing Treg content, medicines for preventing and treating inflammatory bowel disease, and health care products. Background technique [0002] Regulatory cells (Treg) are a subset of T cells that control autoimmune reactivity in the body. [0003] Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis and Crohn's disease (CD), is a chronic idiopathic intestinal inflammatory disease that can affect all parts of the intestinal tract. The main clinical features of the disease include abdominal pain, diarrhea, weight loss, and rectal bleeding, and some patients may also have systemic symptoms of varying degrees. The etiology and pathogenesis of IBD have not yet been fully clarified, and it is generally believed that it is caused by a variety of factors, including genetic factors, immune factors, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P1/00A61P29/00A61P19/02A61P37/02A61P5/14A61P1/16A61P13/12A23L33/00
CPCA23V2002/00A61K45/00A23L33/00A61P1/00A61P1/16A61P5/14A61P13/12A61P19/02A61P29/00A61P37/02A23V2200/32A61K31/519
Inventor 汤慧芳
Owner ZHEJIANG UNIV
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