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External application bamboo cape jasmine five-yellow liquid for treating damaged skin tissues and applications thereof

A technology of Zhuzhi Wuhuang liquid and skin, which is applied in the direction of skin diseases, drug combinations, antipyretics, etc., and can solve problems such as skin tissue damage without application

Inactive Publication Date: 2018-11-16
黄晓蓉 +7
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the perspective of the mechanism of action, Huanglian Jiedu Decoction is mainly used for anti-inflammation, antibacterial, anti-oxidation, anti-cerebral ischemia, antihypertensive, etc., and there are no reports and literatures on the treatment of skin tissue damage and swelling. Openly, from the point of view of administration route, at present, Huanglian Jiedu Decoction is mainly administered orally in clinical practice, and there are clinical reports and published literature on external administration.

Method used

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  • External application bamboo cape jasmine five-yellow liquid for treating damaged skin tissues and applications thereof
  • External application bamboo cape jasmine five-yellow liquid for treating damaged skin tissues and applications thereof
  • External application bamboo cape jasmine five-yellow liquid for treating damaged skin tissues and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] An externally administered Zhuzhiwuhuang liquid for treating damaged skin tissue, comprising the following preparation process:

[0036] Step 1: Add 9 parts of Coptis Rhizoma, 6 parts of Phellodendron Phellodendri, 6 parts of Scutellaria baicalensis, 9 parts of Jiaozhizi, 24 parts of Bamboo Leaf, and 9 parts of Glauber's Salt with water for liquid extraction. Add 13 times the amount of water for the first time, extract for 30 minutes, and extract for the second time Add 10 times the amount of water for the third time, extract for 30 minutes, combine the filtrates extracted three times, and concentrate;

[0037] Step 2: Add 0.36 parts of borneol, add 9 times the amount of 95% ethanol to dissolve, add 3 times the amount of Tween to aid dissolution, mix with the concentrated solution in step 1, and then add distilled water;

[0038] Step 3: Stand still for 24 hours;

[0039] Step 4: subpackage and sterilize the filtrate, and perform quality control;

[0040] Step 5: The ...

experiment example 1

[0075] Experimental example 1: The impact test of Zhuzhiwuhuang liquid of the present invention on mouse ear swelling caused by xylene

[0076] 60 KM mice, male, were randomly divided into 6 groups according to body weight, respectively, model control group (distilled water), vehicle control group (Zhuzhiwuhuang liquid vehicle control group), positive control group (distilled water). Semiasone ointment), high-dose experimental group (2-fold concentrated solution of Zhuzhi Wuhuang Liquid), medium-dose experimental group (Zhuzhi Wuhuang Liquid), and low-dose experimental group (double dilution of Zhuzhi Wuhuang Liquid). Remove the hair from the abdomen of all animals to form a 1.5cm×1.5cm hair removal administration area, and locally administer the corresponding test substance or reference substance in the hair removal area at 0.2ml (g) per animal, once a day, for 3 consecutive days; 40 minutes after the medicine, smear 30ul of xylene on both sides of the right ear of the mouse,...

experiment example 2

[0081] Experimental Example 2: Effect test of Zhuzhi Wuhuang Liquid of the present invention on rat paw swelling caused by egg white

[0082]60 SD rats, male, measured the volume of the left paw, and stratified and randomly divided them into 6 groups, respectively, the model control group (distilled water), the vehicle control group (Zhuzhiwuhuang liquid solvent solution), the positive Control group (dexamethasone ointment), high-dose experimental group (2 times concentrated solution of Zhuzhi Wuhuang Liquid), medium-dose experimental group (Zhuzhi Wuhuang Liquid), low-dose experimental group (double dilution of Zhuzhi Wuhuang Liquid) . Smear the rat's left foot with the corresponding test product or reference product, and the dosage is 0.5ml (g) / rat, once a day, for 3 consecutive days. On the 3rd day, the volume of the left paw of the rat was measured twice, and the average value was used as the base volume; administration was administered after the measurement, and 10% fres...

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PUM

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Abstract

The invention discloses an external application bamboo cape jasmine five-yellow liquid for treating damaged skin tissues. The liquid comprises following components: coptis, phellodendron, radix scutellariae, processed cape jasmine, lophatherum gracile, salt cake, and borneol.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an externally administered Zhuzhiwuhuang liquid for treating skin tissue damage and its use. Background technique [0002] In orthopedic diseases, whether it is a simple fracture or muscle injury or combined with skin and soft tissue defects, infection, whether it is an acute injury or postoperative recovery, the main symptoms of the patient are swelling, pain, and mobility impairment at the injured site. The main reasons are: It is caused by local bacterial or aseptic inflammatory stimulation. The external treatment methods of traditional medicine mainly include external application of traditional Chinese medicine, external washing, wax therapy, etc., which have certain curative effects. For cases with strict technical requirements, this type of treatment is limited. At the same time, there are regrets to varying degrees such as cumbersome operation, difficu...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P29/00A61P17/02A61P31/00A61K33/04A61K31/045
CPCA61K9/0014A61K31/045A61K33/04A61K36/539A61K36/718A61K36/744A61K36/756A61K36/899A61P17/02A61P29/00A61P31/00A61K2300/00
Inventor 黄晓蓉颜月红尉伟卫廖芳吴逢斌唐建军余洋刘运忠
Owner 黄晓蓉
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