Medicine for treating hysteromyoma and preparation method thereof

Abstract

The invention discloses a medicine for treating hysteromyoma and a preparation method thereof. The medicine is characterized in that the effective component of the medicine composition is glycyrrhetinic acid. The invention relates to the medicine for treating hysteromyoma and the preparation method thereof. It is creatively found that glycyrrhetinic acid can effectively inhibit hysteromyoma, and specifically, treatment is achieved through the anti-estrogenic function of glycyrrhetinic acid. Other normal tissue and cells are protected to the largest extent while hysteromyoma is inhibited, and side effects of glycyrrhetinic acid are small.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating uterine fibroids and a preparation method thereof. Background technique [0002] Uterine fibroids, also known as uterine fibroids, are composed of smooth muscle fibers and a small amount of fibrous connective tissue. The former is a special tumor component, and the latter is a supporting tissue, so its exact name is uterine leiomyoma, which is referred to clinically as "uterine fibroids". According to a large number of clinical observations and experimental results, it is found that uterine fibroids are hormone-dependent tumors, and estrogen is the main factor that promotes the growth of fibroids. The clinical manifestations of uterine fibroids vary depending on the location, size, speed, degeneration and complications of fibroids. The most common symptom is uterine bleeding, accounting for more than 1 / 3, manifested as heavy menstruation, prolonged mens...

AI Technical Summary

Problems solved by technology

Looking at the treatment methods, surgical treatment has the following problems: the recurrence rate after myomectomy is as high as 15%-41%, and more than half of the patients need reoperation; The supply is blocked, which will lead to premature ovarian failure; subtotal hysterectomy will cause cervical cancer in 1%-2% of the preserved cervix, and this "stump cancer" will have unexpected effects on surgical treatment and reflexology Difficulties; Intrafascial hysterectomy and central resection of the uterine body are difficult to operate and require high technical skills for doctors

[0004] (1) Androgen, itself a sex hormone, is the earliest clinically used drug for the treatment of uterine fibroids. It has certain effects, but often has relatively large side effects, which limits its application;

[0005] (2) Gonadotropin-releasing hormone agonists, such drugs can significantly reduce the size of fibroids and reduce uterine bleeding. The main side effect of this drug is menopause-like changes related to low estrogen, and long-term use can cause osteoporosis;

At the same time, TAM has the effect of estrogen, and it has been reported that patients with long-term use will develop endometrial cancer, so this drug is used less;

[0008] (5) Naimitong: also known as triene hornolone, according to clinical observations, it can effectively reduce the volume of fibroids, but after using the drug, the incidence of hot flashes, sweating, weight gain, and acne is high and severe, and there are some reversible liver damage

[0009] It can be seen from the above that the current drug treatment will almost inevitably cause ovarian function decline, affect the secretion of estrogen and progesterone, and cause menopausal symptoms, including hot flashes, depression, coronary heart disease, and even osteoporosis, causing masculinization, liver Increased burden, large adverse reactions

Moreover, the long-term curative effect after drug treatment is unsatisfactory. Drug treatment cannot make the fibroids completely shrink and disappear, but only promotes the shrinkage of the fibroids, thereby temporarily improving the uncomfortable symptoms caused by the fibroids.

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