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A maternal and fetal blood group incompatibility immunosorbent therapeutic apparatus

A technology of blood type incompatibility and immunoadsorption, which is applied in the medical field, can solve unseen problems, achieve the effect of easy transportation and storage, and easy industrial application

Inactive Publication Date: 2019-01-08
翁炳焕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above method has been widely used in the detection of pathogens or antigen antibodies, but it has not been applied to absorb pathogenic antibodies of maternal-fetal blood group incompatibility to treat maternal-fetal blood group incompatibility hemolytic disease

Method used

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  • A maternal and fetal blood group incompatibility immunosorbent therapeutic apparatus
  • A maternal and fetal blood group incompatibility immunosorbent therapeutic apparatus
  • A maternal and fetal blood group incompatibility immunosorbent therapeutic apparatus

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Embodiment Construction

[0019] Combine below figure 1 , figure 2 with image 3 , the embodiment of the present invention is described in detail.

[0020] 1. Preparation of anti-blood group antibodies and blood group antigens

[0021] (1) Preparation of anti-Rh(D) blood group antibody

[0022] 1. Preparation of Rh negative lymphocytes

[0023] (1) Primary cell acquisition: purchase 300ml of freshly concentrated Rh-negative white blood cells from the blood bank; and purchase 300ml of fresh Rh-positive red blood cell suspension.

[0024] (2) Preparation of Rh-negative lymphocyte separation: Aseptically extract 20mL of fresh concentrated Rh-negative leukocytes, dilute 3-5 times with PBS solution, mix thoroughly, take 6mL and slowly superimpose on the added 4mL lymphocyte separation solution along the tube wall with a dropper Centrifuge horizontally in a horizontal centrifuge (4000r / min, 20°C) for 35min in a 10mL centrifuge tube; after centrifugation, the tube is divided into 3 layers, the upper lay...

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Abstract

A maternal-fetal blood group incompatibility immunosorbent therapy apparatus used in the medical field is characterized in that a blood separator and a plasma adsorber are connected through a circulation line to form a cardiopulmonary bypass adsorption device, wherein the blood separator is used for separating blood cells and plasma, as the separated plasma flows through and filters through the plasma adsorber, wherein the pathogenic antibody is adsorbed, the filtered plasma is combined with the separated blood cells and then re-enters a cardiopulmonary bypass adsorption device for circulatingadsorption to achieve the purpose of cleaning the pathogenic antibody, and the plasma adsorber is filled with a solid-phase carrier coated with blood group antigen or anti-blood group antibody with high to low gradient titer from an inlet to an outlet in a layered manner.

Description

technical field [0001] The invention relates to a treatment instrument for maternal-fetal blood group incompatibility based on interception of pathogenic antibodies in the medical field, which is mainly used for adsorption and removal of anti-fetal red blood cell antibodies in plasma of pregnant women with maternal-fetal blood group incompatibility. Background technique [0002] Humans have 26 blood types such as ABO, Rh, MN, Lew, and Kell, among which the most important are ABO blood type and Rh blood type. ABO blood type is divided into A according to the A antigen, B antigen, AB antigen or no A and B antigen carried by red blood cells Rh blood type, B type, AB type and O type; Rh blood type is divided into Rh positive and Rh negative according to whether red blood cells carry D antigen, Rh positive red blood cells contain Rh antigen, among which the most antigenic and decisive role is D antigen, Can immunoagglutination with anti-D serum. The frequency of Rh negative in t...

Claims

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Application Information

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IPC IPC(8): A61M1/36
CPCA61M1/3633A61M2202/0413A61M2202/0429A61M2205/02A61M2210/12A61M1/362A61M1/3689A61M2202/0021A61M2202/0064
Inventor 翁炳焕
Owner 翁炳焕
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