Ruthenium (II) complex for treating gastric cancer, as well as preparation method and application thereof

A technology of complexes and uses, applied in the direction of ruthenium organic compounds, compounds containing elements of group 8/9/10/18 of the periodic table, platinum group organic compounds, etc., can solve the problems of limited application, toxicity, etc., and achieve the preparation method Simple, low-cost, molecularly stable effect

Inactive Publication Date: 2019-01-11
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The first generation metal anticancer drug cisplatin has a strong anticancer drug, but its toxicity and other shortcomings limit its application
After decades of research by scientific researchers, several generations of platinum complexes such as carboplatin and oxaliplatin have been synthesized. However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant are still only effective against some tumors. good healing effect

Method used

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  • Ruthenium (II) complex for treating gastric cancer, as well as preparation method and application thereof
  • Ruthenium (II) complex for treating gastric cancer, as well as preparation method and application thereof
  • Ruthenium (II) complex for treating gastric cancer, as well as preparation method and application thereof

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Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

[0022] The chemical name of the ruthenium (II) complex is dichloro-(2-(4-(N-indazolylpiperidinyl)) phenylimidazolyl)-cymenyl ruthenium (II) monochloride;

[0023] Structural formula:

[0024] Physical and chemical properties: red crystal, easily soluble in water and organic solvents, its H NMR spectrum data: 1 H NMR (CDCl 3 solvent):8.53–8.41(m,1H),8.35–8.25(m,1H),7.69–7.57(m,1H),7.55–7.39(m,2H),7.26–7.10(m,2H),7.03– 6.98(m,1H),6.71–6.65(m,1H),5.24(d,1H,J=5.7Hz),4.91(d,1H,J=5.7Hz),4.64(d,1H,J=5.7Hz ),3.91(d,1H,J=5.7Hz),3.62(ddd,J=11.9,11.0,5.5Hz,2H),3.35(ddd,J=11.5,11.0,5.5Hz,2H),2.93(dq, 1H), 2.42–2.25 (m, 4H), 2.69-2.59 (m, 1H), 2.02 (s, 3H), 1.162-1.112 (m, 6H) ppm.

[0025] Preparation:

[0026] 1) 0.366g ruthenium weight content 37% RuCl 3 ·xH 2 0 and 3ml of 95% γ-terpin...

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Abstract

The invention discloses a ruthenium (II) complex. The ruthenium (II) complex is characterized by having a structure as shown in a formula (1). The invention further provides a preparation method and application of the ruthenium (II) complex. The ruthenium (II) complex has relatively strong tumor resistance and ACE inhibition activity, and the preparation method is simple and has low cost and smallraw material consumption.

Description

technical field [0001] The present invention relates to the field of metal complexes. More specifically, the present invention relates to a ruthenium (II) complex and its preparation method and use. Background technique [0002] Cancer is a major threat to human health, and chemotherapy is an important means of treating cancer. The first generation metal anticancer drug cisplatin has a strong anticancer drug, but its toxicity and other shortcomings limit its application. After decades of research by scientific researchers, several generations of platinum complexes such as carboplatin and oxaliplatin have been synthesized. However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant are still only effective against some tumors. Good healing effect. Therefore, there is an urgent need to prepare new metal complexes for the preparation of anti-tumor drugs, so as to provide more and better options for the treatment of tumor diseases. Contents of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00A61P9/12
CPCC07F15/0046A61P9/12A61P35/00
Inventor 李培源霍丽妮
Owner GUANGXI UNIV OF CHINESE MEDICINE
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