50results about How to "Molecular stabilization" patented technology

The invention discloses a compound for enhancing anti-infection capacity of plants disclosed as structural formula (I), and a preparation method and application thereof. The chemical name is monochlorinated-chloro-p-fluoridated-phenyl-2-N<4>-phenylthiosemicarbazidomonomethylisopropylbenzo ruthenium (II). The compound has strong bactericidal activity for Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and Bacillus subtilis black variant (ATCC 9372), has the advantages of excellent mold resistance and no toxicity, has the function of promoting growth of osteoblasts, is used for preparing drugs for enhancing plant performance and preventing plant related infections, and has obvious application potential. The preparation method is simple, and has the advantages of accessible raw materials and low cost.

The invention discloses a dibenzothiophene-thiophene pyrrolidone type double cable conjugate polymer and a preparation method thereof. The method comprises the following steps that alkyl bromide substituted thiophene pyrrolidone and a receptor nucleophilic reagent are added into an organic solvent; after the dissolving and balance, potassium carbonate is added; heating reaction is performed; aftercooling, chloroform and deionized water are added; liquid distribution is performed; organic phases are washed by saline water; drying and rotary evaporation are performed to obtain crude products; the crude products are subjected to silicagel column separation to obtain a pure intermediate M1; (2) the intermediate M1 and a dibenzothiophene type double tin reagent M2 are added into methylbenzene;after the solution is subjected to degasification treatment, a palladium catalyst and triphenylphosphine are added; heating reaction is performed; products are precipitated and filtered; the polymeris separated out in acetone; a filter membrane is used for suction filtration; vacuum drying is performed to obtain a black double cable polymer product. The prepared polymer has the advantages that an electron donor and a receptor are connected to form a single ingredient active layer through covalent bonds; the polymer is applied onto a photovoltaic device and belongs to an organic photovoltaicmaterial with excellent performance.

The invention provides an atmospheric dielectric barrier discharge plasma sterilization device. The device comprises sensors (a temperature sensor, an air pressure sensor and a wind power sensor), an analysis circuit, a power supply control circuit, a plasma generation device and the like. The device adopts the principles of dielectric barrier discharge, preionization and self-inductance, so that the needed power supply voltage can be effectively reduced, the device volume is decreased, and the actual use of the sterilization device is convenient. And above all, breakdown voltage is reduced to more easily ionize gas, that is, plasma is more easily generated under the atmospheric condition, so that the density of the plasma is increased, and the sterilization efficiency of the device is improved. As thin needle tubing is adopted, the jet speed of the plasma is quickened, and the sterilization range of the plasma sterilization device is improved. In addition, the appearance design is more humanized, so that more convenience is brought to the actual operation; and for materials, heat-resistant and insulative engineering plastics with antibacterial effect after the plasma injection treatment are adopted.

The invention relates to tire reclaimed rubber and a preparation method thereof. The tire reclaimed rubber comprises the following components in parts by weight: 90-120 parts of rubber powder, 2-3 parts of resin, 9-12 parts of rosin, 0.8-1.1 parts of an activating agent, 1-3 parts of sulfur, 1-2 parts of a regenerating agent, 2-5 parts of calcium carbonate, 1-4 parts of argil, 1-5 parts of a titanate coupling agent, 3-4 parts of tall oil and 38-45 parts of aromatic hydrocarbon oil. By adopting the design, the sulfur and the resin are put into the reclaimed rubber, so that the overall strengthof the reclaimed rubber is improved; meanwhile on the basis of a preparation process, a seventh zone, namely a shock chilling zone, is added, so that molecules inside the reclaimed rubber can be rapidly stabilized, finally the reclaimed rubber is slowly heated to normal temperature in a normal temperature zone, then the overall toughness of the reclaimed rubber is improved, and requirements of high-quality rubber products are met.

The invention discloses a Trichinella Spiralis larva ES antigen gene vaccine and a preparation method thereof. Trichinella Spiralis larva 43ku and 45ku ES protein genes are respectively inserted to a pVAXI eukaryotic expression vector to obtain recombinant plasmids, and the recombinant plasmids are mixed according to a ratio of 1:1 to prepare a combined recombined DNA vaccine for preventing Trichinella Spiralis infection and improving the worm reduction rate of bodies. After the injection immunization of hindlimb muscles of mice for three weeks, 2000 worms are killed, the worm reduction rate can reach 76.65%, and the quantity of eggs at the tongue tissues of the mice is obviously reduced.

The invention discloses a method for preparing an anti-bacterial and anti-cancer titanium dioxide nanotube from an iridium complex. The method comprises steps as follows: 1), the iridium complex is acquired; 2), the iridium complex is dissolved in ethyl alcohol; 3), the titanium dioxide nanotube is soaked in an iridium complex solution, nitrogen is introduced and microwave processing is performed; 3), the solution is left to stand and cooled to the normal temperature, then the solution is pressurized to 20-25 Mpa, keeps the pressure for 2-3 min and then is depressurized to normal pressure, and centrifugation is performed for 30-60 min; 4), a liquid supernatant after centrifugation is removed, a lower solution and solids are taken and placed in an environment at the temperature of 100-120 DEG C, are pressurized to 20-25 Mpa, keep the pressure for 2-3 min and then are depressurized to the normal pressure, and drying is performed for 20-26 h. With the adoption of the method, anti-bacterial and anti-cancer capacity of the titanium dioxide nanotube is high, growth of harmful cells can be persistently and effectively inhibited, the titanium dioxide nanotube particularly has more remarkable resisting effect on bone cancer, and the medical utilization effect of the titanium dioxide nanotube can be effectively improved.

The invention provides a protective film frame, a preparation method thereof and a protective film assembly. The protective film frame comprises a frame structure and a coating layer coating the surface of the frame structure, and the coating layer comprises a chromium layer or a titanium dioxide layer. The coating layer coats the surface of the frame structure, so that acid radical/ammonia radical ions (SO4<2->, PO4<3-> and NH<4+>) in the frame structure are coated and isolated from the outside, the release of the acid radical/ammonia radical ions (SO4<2->, PO4<3-> and NH<4+>) in the exposureor after-exposure storage period of a photoetching machine is avoided, and the irregular generation of white fog (Haze) by a photomask is avoided. According to the protective film frame, the photomask is prevented from generating the white fog, so that the repeatability defect of the photomask with the white fog on a formed substrate can be effectively avoided, and the yield of the substrate canbe further improved.

The invention provides a novel protein degradation targeting chimeric compound, application and a preparation method thereof. The protein degradation targeting chimeric compound is 2-(2, 6-dioxo-piperidine-3-yl)-4-fluoro-isoindole-1, 3-dione. The preparation method comprises the following steps: S1, carrying out a fluorination reaction on 3-chlorophthalic anhydride to generate 3-fluorophthalic anhydride; and step S2, carrying out a condensation reaction on the 3-fluorophthalic anhydride and 3-amino-2, 6-piperidinedione hydrochloride so as to obtain the 2-(2, 6-dioxo-piperidine-3-yl)-4-fluoro-isoindole-1, 3-dione. According to the protein degradation targeting chimeric body, the compound is moderate in molecular size, good in fluorine leaving performance, small in molecular weight and stable in performance, target protein and E3 ubiquitin enzyme can be effectively close to each other, and the protein degradation targeting chimeric body can be effectively used for preparing targeting drugs. And the preparation method is simple and convenient, less in three wastes and low in raw material price, so that the preparation cost is low, and the method is suitable for industrial large-scaleproduction.

The present invention relates to the isolation of carotenoids and in particular the xanthophyll zeaxanthin (zeaxanthin-β,β-Carotene-3,3′-diol) and optionally other carotenoids such as lycopene, β,β-carotene, 3′-hydroxyechinenone β-cryptoxanthin and the colourless carotenoids, phytoene and phytofluene from a marine bacterium belonging to the genus Algibacter which is capable of producing the aforementioned compounds. The present invention also provides a strain of Algibacter which is capable of producing significant levels of carotenoids, especially zeaxanthin at high purity, as well as methods of using the Algibacter strain and uses of the carotenoids produced.

The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

The invention discloses a compound for treating gastric cancer. The chemical structural formula of the compound is shown in the description. The invention also discloses a preparation method and a useof the compound for treating gastric cancer. The compound for treating gastric cancer contains a benzimidazole and indazole heterocyclic ring, so the obtained compound for treating gastric cancer hasa good bioactivity; and the compound has a large conjugated system, so the molecule is stable. The preparation method has the advantages of simplicity, low cost, no separation or purification steps in the reaction process, reduction of the loss of raw materials, and meeting the requirements of green chemistry.

The invention discloses a ruthenium complex containing N-heterocycle, the structural formula of the ruthenium complex containing N-heterocycle is shown as formula (I) in the following description. Theruthenium complex containing N-heterocycle has stronger anti-tumor activity, has a good prospect of application to the treatment of gastric cancer and liver cancer and the like.

The invention provides an organic blue OLED fused ring compound, a preparation method and an organic electroluminescent device thereof, and belongs to the technical field of organic semiconductors. The organic blue OLED fused ring compound adopts a structure shown as a formula (1).

The invention discloses a ruthenium (II) complex. The ruthenium (II) complex is characterized by having a structure as shown in a formula (1). The invention further provides a preparation method and application of the ruthenium (II) complex. The ruthenium (II) complex has relatively strong tumor resistance and ACE inhibition activity, and the preparation method is simple and has low cost and smallraw material consumption.

The invention discloses an aryl ruthenium complex having the structure as shown in the formula (I), and further provides a preparation method and application of the aryl ruthenium complex. The aryl ruthenium complex has high antineoplastic activity and ACE-inhibiting activity; the preparation method thereof is simple and low in cost, with low loss of raw materials.

The invention provides an electron injection material. The electron injection material is shown as a formula (I), wherein R1 and R2 are each independently a substituted or unsubstituted alkylamino group, a substituted or unsubstituted heterocyclic group and a derivative group of the substituted or unsubstituted heterocyclic group. Compared with the prior art, the adamantane organic base provided by the invention takes adamantanamine as a core, meanwhile, a structure capable of transmitting electrons is connected as an electron injection material; hydrogen bonds can be formed with an electron transport material, high electron injection capacity is achieved, ionization energy does not need to be considered, the electron injection material is easy to synthesize and stable in molecule, molecules have flexible branched chains while hydrogen bonds are formed, an ink-jet material is convenient to prepare, the material can be used for evaporation direct coating, a device can be manufactured inan ink-jet mode, and cost reduction is facilitated.

The invention discloses a molecular probe derived from a calcium-sensitive receptor protein antagonist and application of the molecular probe in parathyroid gland resection surgery. The molecular probe is specifically a molecular probe which is derived from a chiral calcium-sensitive protein inhibitor antagonist Calhex 231 and contains a fluorophore as shown in a general formula A1 or a molecular probe containing a chromophore as shown in a general formula A2, wherein the structures of general formula A1 and general formula A2 are shown in specification.

The present invention relates to variants having alpha-amylase activity and polynucleotides encoding the variants. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the variants.