Method for preparing anti-bacterial and anti-cancer titanium dioxide nanotube from iridium complex

A technology of iridium complexes and titanium dioxide, applied in the direction of medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulations, etc., to achieve the effects of molecular stability, good binding effect, and good biological activity

Active Publication Date: 2016-02-17
嘉兴慧泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of iridium complexes with antibacterial effects to improve the antibacterial effect of titanium dioxide nanotubes has not been reported. In particular, the iridium complexes also have anti-cancer effects, especially anti-bone cancer, and can simultaneously endow titanium dioxide nanotubes with antibacterial and antibacterial properties. Anti-cancer, especially anti-bone cancer ability

Method used

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  • Method for preparing anti-bacterial and anti-cancer titanium dioxide nanotube from iridium complex
  • Method for preparing anti-bacterial and anti-cancer titanium dioxide nanotube from iridium complex
  • Method for preparing anti-bacterial and anti-cancer titanium dioxide nanotube from iridium complex

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Experimental program
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Effect test

Embodiment 1

[0025] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0026] 1) Dissolve 3.5g of o-carboxybenzaldehyde in 10ml of toluene, add 10g of 1-(9-anthracenyl)ethanol, add 1ml of sulfuric acid with a concentration of 98%, heat, stir and reflux at 110°C for 2h, spin the filtrate to dryness, add 5ml of ethyl acetate extraction, repeating the ethyl acetate extraction process 4 times, combining the ethyl acetate layer solution, adding 10g of anhydrous potassium carbonate to dry, the solution was spin-dried to obtain o-anthracenoxycarbonylbenzaldehyde having the formula (1);

[0027]

[0028] 2) Dissolve 4g of o-anthroxyylbenzaldehyde in 10ml of absolute ethanol, add 1g of thiosemicarbazide, reflux and stir at 60-70°C, react for 6h to obtain a slightly purple solution, spin dry to 1ml, add 4ml of ethanol and 5ml Normal hexane, the white crystal that separates out is the o-anthracenoxyacylbenzaldehyde thio...

Embodiment 2

[0037] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0038] 1) Dissolve 2g of o-carboxybenzaldehyde in 5ml of toluene, add 5g of 1-(9-anthracenyl)ethanol, add 1ml of sulfuric acid with a concentration of 98%, heat, stir and reflux at 110°C for 2h, spin the filtrate to dryness, and add 5ml Ethyl acetate extraction, repeating the ethyl acetate extraction process 4 times, combining the ethyl acetate layer solution, adding 10 g of anhydrous potassium carbonate for drying, and spinning the solution to dryness to obtain o-anthracenoxycarbonylbenzaldehyde having the formula (1);

[0039]

[0040] 2) Dissolve 3g o-anthroxyylbenzaldehyde in 8ml of absolute ethanol, add 1g of thiosemicarbazide, stir under reflux at 60°C, react for 5h to obtain a slightly purple solution, spin dry to 1ml, add 3ml of ethanol and 4ml of n-hexane , white crystals are separated out to be o-anthracenoxyacylbenzaldehyde thio...

Embodiment 3

[0049] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0050]1) Dissolve 4.5g of o-carboxybenzaldehyde in 15ml of toluene, add 15g of 1-(9-anthracenyl)ethanol, add 2ml of sulfuric acid with a concentration of 98%, heat, stir and reflux at 110°C for 3h, spin the filtrate to dryness, add 10ml of ethyl acetate extraction, repeated 5 times of ethyl acetate extraction process, combined ethyl acetate layer solution, added 15g of anhydrous potassium carbonate to dry, the solution was spin-dried to obtain o-anthracenoxycarbonylbenzaldehyde having formula (1);

[0051]

[0052] 2) Dissolve 5g o-anthroxyylbenzaldehyde in 12ml of absolute ethanol, add 2g of thiosemicarbazide, stir under reflux at 70°C, react for 10h to obtain a slightly purple solution, spin dry to 2ml, add 6ml of ethanol and 6ml of n-hexane , white crystals are separated out to be o-anthracenoxyacylbenzaldehyde thiosemicarbazide with fo...

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Abstract

The invention discloses a method for preparing an anti-bacterial and anti-cancer titanium dioxide nanotube from an iridium complex. The method comprises steps as follows: 1), the iridium complex is acquired; 2), the iridium complex is dissolved in ethyl alcohol; 3), the titanium dioxide nanotube is soaked in an iridium complex solution, nitrogen is introduced and microwave processing is performed; 3), the solution is left to stand and cooled to the normal temperature, then the solution is pressurized to 20-25 Mpa, keeps the pressure for 2-3 min and then is depressurized to normal pressure, and centrifugation is performed for 30-60 min; 4), a liquid supernatant after centrifugation is removed, a lower solution and solids are taken and placed in an environment at the temperature of 100-120 DEG C, are pressurized to 20-25 Mpa, keep the pressure for 2-3 min and then are depressurized to the normal pressure, and drying is performed for 20-26 h. With the adoption of the method, anti-bacterial and anti-cancer capacity of the titanium dioxide nanotube is high, growth of harmful cells can be persistently and effectively inhibited, the titanium dioxide nanotube particularly has more remarkable resisting effect on bone cancer, and the medical utilization effect of the titanium dioxide nanotube can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of antibacterial and anticancer titanium dioxide nanotubes, more specifically, a method for preparing antibacterial and anticancer titanium dioxide nanotubes by using an iridium complex. Background technique [0002] Orthopedic and dental implants play an extremely important role in plastic surgery and surgery, but the problem of bacterial infection has led to the failure of a large number of transplant operations, and it is urgent to find a solution to bacterial infection. At present, there have been some reports on improving the antibacterial ability of titanium metal, such as using antibacterial molecules such as antibiotics to improve the antibacterial effect of titanium metal. Compared with titanium metal, titanium dioxide nanotubes can promote the formation of osteoblasts, and show great potential and advantages in the application of implants. At the same time, due to its unique physical and chemical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/54A61L27/50A61K31/555A61P35/00A61P31/04
CPCA61K31/555A61L27/06A61L27/50A61L27/54A61L2300/224A61L2300/404A61L2300/416A61L2300/606
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司
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