Molecular probe derived from calcium-sensitive receptor protein antagonist and application of molecular probe in parathyroid gland resection surgery

A technology of molecular probes and calcium sensitive proteins, applied in the field of molecular probes, can solve the problems of large number, high failure rate, and small tissue, and achieve the effects of small molecular weight, high safety, and high selectivity
CN113173891AInactive Publication Date: 2021-07-27THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
Publication Date
2021-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a molecular probe derived from a calcium-sensitive receptor protein antagonist and application of the molecular probe in parathyroid gland resection surgery. The molecular probe is specifically a molecular probe which is derived from a chiral calcium-sensitive protein inhibitor antagonist Calhex 231 and contains a fluorophore as shown in a general formula A1 or a molecular probe containing a chromophore as shown in a general formula A2, wherein the structures of general formula A1 and general formula A2 are shown in specification.
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Description

technical field

[0001] The present invention relates to a method capable of quickly and specifically identifying parathyroid glands during parathyroidectomy, synthesis and application of image-guided molecular probes, in particular to design, synthesis and application of a calcium-sensing receptor protein Antagonist (Calhex 231)-derived molecular probes that may facilitate parathyroidectomy in secondary hyperparathyroidism surgery. Background technique

[0002] Secondary hyperparathyroidism is an important complication of uremia, which greatly reduces the survival rate and quality of life of patients. Parathyroidectomy is an ideal treatment for secondary hyperparathyroidism in uremia. However, the main problems at present are: 1) Due to the small size of the parathyroid gland tissue, the large number (5-7 or more), the wide distribution, and the difficulty of distinguishing it from the surrounding lymph nodes and adipose tissue, etc., the parathyroid gland tissue The failur...

Claims

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