A compound for improving the anti-infection ability of implants and its preparation method and application

Abstract

The invention discloses a compound for enhancing anti-infection capacity of plants disclosed as structural formula (I), and a preparation method and application thereof. The chemical name is monochlorinated-chloro-p-fluoridated-phenyl-2-N<4>-phenylthiosemicarbazidomonomethylisopropylbenzo ruthenium (II). The compound has strong bactericidal activity for Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and Bacillus subtilis black variant (ATCC 9372), has the advantages of excellent mold resistance and no toxicity, has the function of promoting growth of osteoblasts, is used for preparing drugs for enhancing plant performance and preventing plant related infections, and has obvious application potential. The preparation method is simple, and has the advantages of accessible raw materials and low cost.

Description

technical field

[0001] The invention relates to the field of compound preparation, in particular to an aryl ruthenium complex for improving the anti-infection ability of implants, a preparation method and application thereof. Background technique

[0002] Implant materials such as dental implants and bone implants have become an important repair method for dentition defects and bone loss. However, this type of surgery has a high infection rate, which may lead to serious consequences such as heavy antibiotic treatment, implant removal and even death. There are two main reasons for the high incidence of implant-associated infection: the accumulation of bacterial plaque on the implant surface and the low resistance of the implant osseointegration interface. In order to avoid implant-associated infection, the graft should have excellent properties in two aspects: excellent antibacterial properties and the function of promoting osteoblast growth. Therefore, it is necessary to fi...

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