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Ruthenium complex containing N-heterocycle as well as preparation method and application

A technology of ruthenium complexes and nitrogen heterocycles, which is applied in the field of metal complexes to achieve high anti-tumor activity, low cost, and reduced raw material loss

Inactive Publication Date: 2018-11-23
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors

Method used

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  • Ruthenium complex containing N-heterocycle as well as preparation method and application
  • Ruthenium complex containing N-heterocycle as well as preparation method and application
  • Ruthenium complex containing N-heterocycle as well as preparation method and application

Examples

Experimental program
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preparation example Construction

[0036] 1) Preparation of small polypeptide molecules, using amino acid-king resin as the carrier (resin), fully swelling the resin with dichloromethane, washing several times with dimethylformamide, and using DBLK (volume ratio piperidine: DMF = 1: 4), remove the Fmoc-protecting group (Fmoc is 9-fluorenylmethoxycarbonyl, which can be used as an amino protecting group), then wash several times with dimethylformamide, wash away DBLK, and weigh a suitable condensing agent Benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate and the activator methylmorpholine and the second Fmoc-protected amino acid at the C-terminus (Fmoc-Pro-OH) were used for coupling The connection is detected by the ninhydrin detection method to ensure that the connection is relatively complete, washed several times with dimethylformamide to wash away the remaining residues, activators and condensation agents, coupled according to the amino acid sequence, and all the After the amino acid connection i...

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Abstract

The invention discloses a ruthenium complex containing N-heterocycle, the structural formula of the ruthenium complex containing N-heterocycle is shown as formula (I) in the following description. Theruthenium complex containing N-heterocycle has stronger anti-tumor activity, has a good prospect of application to the treatment of gastric cancer and liver cancer and the like.

Description

technical field [0001] The present invention relates to the technical field of metal complexes. More specifically, the present invention relates to ruthenium complexes with nitrogen-containing heterocycles and their preparation methods and applications. Background technique [0002] Malignant tumor has a high fatality rate and is one of the most important diseases that endanger human health. So far, there is still no effective treatment. Most of the anti-tumor drugs in clinical application belong to nucleoside drugs. These drugs have similar anti-tumor spectrum and have strong toxic and side effects. On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, and tumor cell lines are also prone to mutation. Therefore, the development of anti-tumor drugs that can overcome drug resistance or have broad-spectrum activity has attracted attention. The anti-tumor spectrum and anti-tumor mechanism of metal complexes are different from those of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00A61P9/12A61P3/06A61P3/04A61P3/10A61L31/04A61L31/08A61L31/16
CPCA61L31/048A61L31/08A61L31/16A61L2300/224A61L2300/416A61L2300/606A61P3/04A61P3/06A61P3/10A61P9/12A61P35/00C07F15/0046C08L23/06
Inventor 苏炜彭炳华
Owner GUANGXI TEACHERS EDUCATION UNIV
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