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Functional terahertz slot nanometer antenna for detecting cell exosome without mark

A nano-antenna and exosome technology, which is applied in the field of terahertz measurement, can solve the problems that cannot meet the requirements, achieve the effect of facilitating the detection process of polarized THz spectrum and improving the absorption cross section

Active Publication Date: 2019-01-18
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the existing research work only uses the drop coating method to make the excess biomolecular solution penetrate into the slit for measurement, and for the measurement of trace target substances in body fluid samples, this method obviously cannot meet the requirements

Method used

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  • Functional terahertz slot nanometer antenna for detecting cell exosome without mark
  • Functional terahertz slot nanometer antenna for detecting cell exosome without mark
  • Functional terahertz slot nanometer antenna for detecting cell exosome without mark

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Embodiment

[0038] Such as figure 1 As shown, the functionalized terahertz slit nano-antenna for label-free detection of cellular exosomes includes a substrate and a metal film 1 sputtered on its surface. The substrate includes double-polished high-resistance silicon 3 and formed by oxidation on its surface The silicon dioxide layer 2, the metal film 1 is provided with several groove structures with the silicon dioxide layer 2 as the bottom, and the bottom of the groove structure is oriented and coated with the aptamer 5 sequence, which is used to specifically bind to the surface of the exosomes 4 molecular.

[0039] The thickness of the double-polished high-resistance silicon 3 is 500 μm, and the resistivity is greater than 10000 Ω·cm. The thickness of the silicon dioxide layer 2 is 200 nm. The metal film 1 includes an upper layer and a lower layer, which are respectively a gold film and a chromium film, with thicknesses of 200 nm and 20 nm, respectively.

[0040] The shape of the groove st...

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Abstract

The invention relates to a functional terahertz slot nanometer antenna for detecting cell exosome without a mark. The functional terahertz slot nanometer antenna comprises a substrate and a metal film, wherein the metal film is sputtered onto a surface of the substrate, the substrate comprises dual-throw high-resistance silicon and a silicon dioxide layer, the silicon dioxide layer is formed by oxidization of the surface of the dual-throw high-resistance silicon, a plurality of groove structures are formed in the metal film and take the silicon dioxide layer as a bottom, the bottom of the groove structure is directionally coated with an adapter sequence, a target molecule on a surface of the exosome can be specially combined, and the exosome is fixed at a sensitive response region.

Description

Technical field [0001] The invention belongs to the technical field of terahertz measurement, and relates to a functionalized terahertz slit nano antenna for label-free detection of cell exosomes. Background technique [0002] Exosomes are spherical membranous vesicles with a diameter of 30-120nm secreted by living cells, which contain proteins (CD9, CD63, CD81 and other transmembrane protein superfamily members), DNA, RNA (mRNA, microRNA) And non-coding RNA) and lipids. Exosomes are widely distributed in body fluids such as peripheral blood, saliva, ascites, cerebrospinal fluid, and urine. They participate in the transmission and exchange of information between cells, and play a role in various physiological or pathological processes such as tumor occurrence, development, drug resistance, and tissue damage repair. Important role. The contents of exosomes secreted by different cells are different, especially the specific proteins and miRNAs they carry, which can be used for tum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3586G01N21/3577H01Q1/38B82Y30/00
CPCB82Y30/00G01N21/3577G01N21/3586H01Q1/38
Inventor 赵祥府伟灵张立群王云霞熊瑜
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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