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Functionalized terahertz slit nanoantennas for label-free detection of cellular exosomes

A nano-antenna and exosome technology, applied in the field of terahertz measurement, can solve problems such as inability to meet requirements, achieve the effect of facilitating the detection process of polarization THz spectrum and improving the absorption cross-section

Active Publication Date: 2019-07-09
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the existing research work only uses the drop coating method to make the excess biomolecular solution penetrate into the slit for measurement, and for the measurement of trace target substances in body fluid samples, this method obviously cannot meet the requirements

Method used

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  • Functionalized terahertz slit nanoantennas for label-free detection of cellular exosomes
  • Functionalized terahertz slit nanoantennas for label-free detection of cellular exosomes
  • Functionalized terahertz slit nanoantennas for label-free detection of cellular exosomes

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Embodiment

[0038] Such as figure 1 As shown, the functionalized terahertz slit nanoantenna for label-free detection of cellular exosomes includes a substrate and a metal film 1 sputtered on its surface. Silicon dioxide layer 2, several groove structures with silicon dioxide layer 2 as the bottom are set on the metal film 1, and the bottom of the groove structure is oriented to coat the aptamer 5 sequence, which is used to specifically bind the surface of the exosome 4 molecular.

[0039] The thickness of the double-thrown high-resistance silicon 3 is 500 μm, and the resistivity is greater than 10000 Ω·cm. The silicon dioxide layer 2 has a thickness of 200 nm. The metal film 1 includes an upper layer and a lower layer, which are a gold film and a chromium film respectively, and the thicknesses are 200nm and 20nm respectively.

[0040] The shape of the groove structure is circular, the distribution period is 120 μm, the outer radius is 40 μm, the inner radius is 39.5 μm, and the gap is ...

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Abstract

The invention relates to a functional terahertz slot nanometer antenna for detecting cell exosome without a mark. The functional terahertz slot nanometer antenna comprises a substrate and a metal film, wherein the metal film is sputtered onto a surface of the substrate, the substrate comprises dual-throw high-resistance silicon and a silicon dioxide layer, the silicon dioxide layer is formed by oxidization of the surface of the dual-throw high-resistance silicon, a plurality of groove structures are formed in the metal film and take the silicon dioxide layer as a bottom, the bottom of the groove structure is directionally coated with an adapter sequence, a target molecule on a surface of the exosome can be specially combined, and the exosome is fixed at a sensitive response region.

Description

technical field [0001] The invention belongs to the technical field of terahertz measurement, and relates to a functionalized terahertz slit nano antenna for label-free detection of cellular exosomes. Background technique [0002] Exosomes are spherical membranous vesicles secreted by living cells with a diameter of 30-120 nm, which contain proteins (CD9, CD63, CD81 and other members of the transmembrane protein superfamily), DNA, RNA (mRNA, microRNA and non-coding RNA) and lipids. Exosomes are widely distributed in body fluids such as peripheral blood, saliva, ascites, cerebrospinal fluid, and urine, participate in the transmission and exchange of information between cells, and play a role in various physiological or pathological processes such as tumor occurrence, development, drug resistance, and tissue damage repair. important role. There are differences in the contents of exosomes secreted by different cells, especially the specific proteins and miRNAs carried by them...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/3586G01N21/3577H01Q1/38B82Y30/00
CPCB82Y30/00G01N21/3577G01N21/3586H01Q1/38
Inventor 赵祥府伟灵张立群王云霞熊瑜
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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