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Sampling device based on induction electrospray and mass spectrometry method

A sampling device and mass spectrometry technology, applied in the field of mass spectrometry, can solve problems such as difficult adjustment of spraying time and intensity of different samples, failure to meet the needs of high-throughput automatic detection, etc., to meet the requirements of high-throughput array analysis, device Simple and effective in improving detection efficiency

Pending Publication Date: 2019-01-25
HUA YUE ENTERPRISE HLDG LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. It is difficult to adjust the spray time and intensity for different samples
[0005] 2. At present, this method can only realize the analysis of a single sample, which cannot meet the detection requirements of high-throughput automation

Method used

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  • Sampling device based on induction electrospray and mass spectrometry method
  • Sampling device based on induction electrospray and mass spectrometry method
  • Sampling device based on induction electrospray and mass spectrometry method

Examples

Experimental program
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Effect test

Embodiment 1

[0033] figure 1 Schematically provides a simplified structural diagram of the mass spectrometry system of Example 1 of the present invention, as figure 1 As shown, the mass spectrometry system includes:

[0034] Mass spectrometry inlet 61;

[0035] A sampling device based on induction electrospray, which includes:

[0036] At least two spray needles, the spray needle includes a capillary 21, an electrode 22 and a distance adjustment member 23, and the distance adjustment member adjusts the distance between the electrode and the capillary; the outer diameter of the capillary is 1-1.2mm, and the inner diameter is 0.6-0.8mm, the diameter of the front nozzle is 1-3μm; the distance adjustment part is a spring or a cam;

[0037] A first drive unit 11, the at least two spray needles are driven to translate under the drive of the first drive unit;

[0038] The power supply electrode 32, the only power supply electrode is suitable for connecting to an external power supply;

[003...

Embodiment 2

[0056] An application example of the inductive electrospray-based sampling device and method in the detection of cyclamate according to Embodiment 1 of the present invention.

[0057] In this application example, only one power supply electrode is covered by an insulating shell, and the central axis of the power supply electrode and the mass spectrometer inlet is collinear; both the first drive unit and the second drive unit use a combination of a motor and a guide rail; The driving directions of the first drive unit and the second drive unit are vertical: the first drive unit drives the spray needle to translate horizontally back and forth, and the second drive unit drives the power supply electrode to horizontally translate left and right; the fixture is a tubular structure, and the electrode and the spring (as the distance Adjusting part) is set in the fixing part, when the electrode is driven by the power supply electrode, the spring is compressed, thereby adjusting the dis...

Embodiment 3

[0060]Application example of the sampling device and method based on inductive electrospray in the detection of sorbic acid according to Embodiment 1 of the present invention.

[0061] In this application example, only one power supply electrode is covered by an insulating shell, and the power supply electrode and the central axis of the mass spectrometer inlet are collinear; both the first drive unit and the second drive unit use a combination of a motor and a guide rail; The driving directions of the first drive unit and the second drive unit are vertical: the first drive unit drives the spray needle to translate horizontally back and forth, and the second drive unit drives the power supply electrode to horizontally translate left and right; the fixture is a tubular structure, and the electrode and the spring (as the distance Adjusting part) is set in the fixing part, when the electrode is driven by the power supply electrode, the spring is compressed, thereby adjusting the d...

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Abstract

The invention provides a sampling device based on induction electrospray and a mass spectrometry method. The sampling device based on the induction electrospray comprises at least two spray needles, wherein each spray needle comprises a capillary tube, an electrode and a distance adjusting member for adjusting the distance between the electrode and the capillary tube; a first driving unit for driving at least two spray needles to translate; a power supply electrode for connecting an external power supply; a second driving unit for driving the power supply electrode to translate in the direction parallel to the extending direction of the spray needles to enable the power supply electrode to contact and break away from electrodes in the spray needles. The device has the advantages of simplestructure, high detection efficiency and the like.

Description

technical field [0001] The invention relates to mass spectrometry analysis, in particular to a sampling device based on induction electrospray, a mass spectrometry analysis system and a working method thereof. Background technique [0002] In the field of mass spectrometry, Nano-ESI technology is the most important method to achieve small volume sample injection and ionization. Due to the reduced diameter of the nozzle, Nano-ESI can greatly reduce the flow rate of the solution, and at the same time, the jet droplets generated are smaller than the general electrospray, and the sample ionization efficiency is high. However, when performing Nano-ESI analysis, the contact between the electrode and the sample solution will cause a serious problem of dead volume, which will affect the detection sensitivity. In addition, when analyzing pL-level sample solutions, Nano-ESI can only produce instantaneous sprays, and it is difficult to achieve multi-stage mass spectrometry analysis, w...

Claims

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Application Information

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IPC IPC(8): G01N27/64
CPCG01N27/64
Inventor 闻路红周镇宇洪欢欢赵鹏陈腊毕磊
Owner HUA YUE ENTERPRISE HLDG LTD
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