Solid dispersion matrix and application thereof

Abstract

The invention belongs to the technical field of a solid dispersion, and concretely relates to a solid dispersion matrix and an application thereof. The solid dispersion matrix is an eutectic system composed of a hydrogen bond donor, a hydrogen bond acceptor, and an excipient, and the hydrogen bond donor is any one or more of glucose, mannitol, citric acid, succinic acid, and menthol; the hydrogenbond acceptor is choline chloride; and the excipient is any one or more of PEG, PVP and poloxamer. The beneficial effects of the solid dispersion matrix are as follows: firstly, the dissolution of aninsoluble drug in water is improved, and the utilization degree is greatly improved; secondly, the eutectic system is used as the solid dispersion matrix for preparing pills, water-dispersible granules or wettable powder, the process is simple, the operation is easy, the solid dispersion matrix does not use toxic and harmful organic solvents, is non-polluting, and is suitable for industrial production; and furthermore, the addition of excipient improves the storage stability of the prepared drug and is less susceptible to wetting liquefaction.

Description

technical field [0001] The invention belongs to the technical field of solid dispersion, and in particular relates to a solid dispersion matrix and its application. Background technique [0002] The eutectic phenomenon refers to the phenomenon of wetting or liquefaction after two or more drugs are mixed, and the melting point of the eutectic system is significantly lower than that of any component. As a new class of green solvents, deep eutectic solvents have unique physical and chemical properties such as low vapor pressure, non-toxicity, biodegradability, excellent solubility and conductivity, and wide electrochemical stability window. It has attractive application prospects in many fields to adjust its performance by matching ratio. The invention mainly utilizes the solubilizing effect of the eutectic system to make the drug and the eutectic system generate hydrogen bonds with each other, so as to fully disperse the drug and increase its dissolution in water. [0003] S...

AI Technical Summary

Problems solved by technology

Making emulsifiable concentrate requires a large amount of organic solvents, which is not good for the environment. After the drug is micronized, the surface free energy is relatively large, and there is a tendency of spontaneous aggregation. The particle size cannot always meet the standard, which reduces the pulverization effect.

At present, there is a technology for dispersing insoluble drugs in the eutectic system with choline chloride as the hydrogen bond acceptor, but this system is very easy to absorb moisture, and the solid state material will liquefy after being placed for a period of time, while the simple With PEG as the solid dispersion matrix, the dissolution rate in water is slow, and the high content of polymer materials can easily cause the solution viscosity to be too high

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