A kind of drug-loaded electrospun fiber membrane and preparation method thereof

An electrospun fiber and drug-loading technology, which is applied in the directions of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problems of dose-limiting toxicity and limited therapeutic effect, clinical application restrictions, etc., and achieve good drug sustained-release performance and preparation method Convenient and broad application prospects

Active Publication Date: 2022-04-15
GUANGDONG PROV MEDICAL INSTR INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although CPT has been proven to have antitumor effects, its clinical application is severely limited by dose-limiting toxicity and limited therapeutic effect.

Method used

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  • A kind of drug-loaded electrospun fiber membrane and preparation method thereof
  • A kind of drug-loaded electrospun fiber membrane and preparation method thereof
  • A kind of drug-loaded electrospun fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Accurately weigh 1000 mg of PLGA (1:1 ratio of PLA and PGA, molecular weight of 44,000) and PF127 with a balance, dissolve them in a mixed solution of dichloromethane and methanol (solution volume ratio: 8:2), and prepare PLGA / PF127 mass ratio gradient of 5:1, 4:1, 3:1, 2:1, 1:1, 1:2 solution, so that the PLGA mass concentration is 14%, seal the bottle to prevent solvent volatilization, vortex Until it is completely dissolved, the polymer electrospinning solution is obtained. Through electrospinning, adjust the process control parameters of the electrospinning instrument (instrument input voltage 3V, output voltage 10KV), such as flow rate (0.2mL / min, 0.4mL / min, 0.6mL / min) and receiving distance (5cm, 6cm, 7cm, 8cm, 9cm), screen out the optimal concentration: the fiber membrane has a good general appearance and a uniform fiber membrane under the microscopic appearance. After the electrospun membrane was obtained, it was placed on an ultra-clean workbench to avoid ligh...

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Abstract

The invention discloses a drug-loaded electrospun fiber membrane, which is composed of antitumor drugs and carrier materials, and is characterized in that the antitumor drugs contain camptothecin and curcumin; the invention also discloses a preparation method of the fiber membrane. As a new anti-tumor drug carrier, the fiber membrane has excellent biocompatibility, degradability, and good drug sustained release performance, and has broad application prospects. It has good biocompatibility and degradability, and the drug can be gradually released from the slow-release carrier, thereby maintaining a stable and effective concentration, which can effectively inhibit the growth of tumor cells, has excellent anti-tumor effect, and has a convenient preparation method. low cost.

Description

technical field [0001] The invention relates to a drug-loaded electrospun fiber membrane and a preparation method thereof, in particular to an electrospun fiber membrane loaded with two antitumor drugs and a preparation method thereof. Background technique [0002] Cancer is one of the main causes of human death, and chemotherapy is one of the main methods of cancer treatment. Tumor multidrug resistance is currently the biggest obstacle to cancer chemotherapy. Studies have shown that: after the tumor cells in the growth phase are in contact with chemotherapy drugs, they not only develop resistance to the chemotherapy drugs, but also produce cross-resistance to other drugs with different structures and functions. In clinical practice, about half of chemotherapy patients are completely resistant to chemotherapy drugs, or even if they are effective for a short period of time, they will develop drug resistance again, which brings great difficulties to tumor chemotherapy. [00...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/70A61K47/34A61K31/4745A61K31/12A61P35/00
CPCA61K47/34A61P35/00A61K9/7007A61K31/12A61K31/4745A61K2300/00
Inventor马盼盼肖波刘群峰顾珩黄德群耿志杰张丽裴大婷张锦陈秋冰苟双全黄亚梅周信马雅
OwnerGUANGDONG PROV MEDICAL INSTR INST