NaErF4@NaYF4-folic acid stokes shifts probe and preparation method thereof

A probe, folic acid technology, applied in the field of lung adenocarcinoma detection, can solve the problems that have not been reported in the literature, and achieve the effects of low cost, no radiation, high sensitivity, and high feedback speed

Inactive Publication Date: 2019-03-22
SHANGHAI PULMONARY HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no literature report on the imaging diagnosis technology based on rare earth nanoparticle carrier in lung cancer.

Method used

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  • NaErF4@NaYF4-folic acid stokes shifts probe and preparation method thereof
  • NaErF4@NaYF4-folic acid stokes shifts probe and preparation method thereof
  • NaErF4@NaYF4-folic acid stokes shifts probe and preparation method thereof

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Experimental program
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Effect test

Embodiment Construction

[0046] 1. Probe Preparation

[0047] 1.1 Preparation of shell precursor

[0048] Preparation of Gd-OA (0.1M) precursor: In a 50mL three-neck round bottom flask, first add 2.5mmolGdCl3, 10mL oleic acid, and 15mL octadecene. Then heated to 140 °C under vacuum and magnetic stirring conditions and kept for 1 hour, and finally a clear and transparent Gd-OA (0.1M) precursor was obtained.

[0049] Preparation of Y-OA (0.1M) precursor: In a 50mL three-neck round bottom flask, first add 2.5mmolYCl3, 10mL oleic acid, and 15mL octadecene. Then heated to 140 °C under vacuum and magnetic stirring conditions and kept for 1 hour, and finally a clear and transparent Y-OA (0.1M) precursor was obtained.

[0050] Preparation of Na-TFA-OA precursor: In a 25mL three-necked round-bottomed flask, add 4mmol sodium trifluoroacetate and 10mL oleic acid in sequence, keep room temperature, dissolve under vacuum and stirring conditions, and finally obtain colorless, transparent and clear Na- TFA-OA pre...

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Abstract

The invention discloses a NaErF4@NaYF4-folic acid stokes shifts probe. The NaErF4@NaYF4-folic acid stokes shifts probe is characterized in that a stokes shifts nanocrystalline complex is prepared by combining rare earth stokes shifts nanocrystals with a folic acid target head so as to obtain a near-infrared probe, and the characterization data of the probe is as follows: an emission peak of the probe is 1532 nm, and the average particle size of the crystals is 25.43 nm. The invention also discloses a preparation method of the NaErF4@NaYF4-folic acid stokes shifts probe. For the prepared probe,the stokes shifts nanocrystalline complex is prepared by combining the rare earth stokes shifts nanocrystals with the folic acid target head so as to obtain a novel near-infrared probe for recognizing lung adenocarcinoma. The NaErF4@NaYF4-folic acid stokes shifts probe can more accurately guide the scope of a surgery during the surgery and enables the surgery to be more precise.

Description

technical field [0001] The invention relates to the field of lung adenocarcinoma detection, in particular to a NaErF4@NaYF4-folate down-conversion probe and a preparation method thereof. Background technique [0002] Currently, there are many examination methods for tumor tissue lesions in the body, including CT, MRI (magnetic resonance imaging), color Doppler ultrasound, PET-CT, etc. Compared with traditional tomographic imaging techniques, optical bioimaging based on the principle of photoluminescence has the advantages of high feedback speed, high imaging resolution, high sensitivity, low cost and no radiation. There are many studies on quantum dot fluorescent materials and organic fluorescent dyes. Among them, semiconductor quantum dots can make up for the shortcomings of organic fluorescent dyes such as poor photostability, wide emission peaks, and easy photobleaching and photolysis. However, there are many shortcomings, such as easy Flashing, high toxicity, poor chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85C09K11/02B82Y20/00B82Y30/00B82Y40/00G01N21/64G01N21/359
CPCB82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/7705G01N21/359G01N21/6428G01N21/6486
Inventor 朱军
Owner SHANGHAI PULMONARY HOSPITAL
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