Application of zerumbone or prodrugs thereof to preparation of calming drugs

A kind of zingerone, the technology of use, is applied in the field of zingerone or its prodrug for preparing sedative medicine, can solve the problems such as no sedative effect of zingerone

Inactive Publication Date: 2019-03-29
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, it can be seen that zingerone has definite anti-tumor and anti-inflammatory therapeutic effects, but there are no related reports that zingerone has a sedative effect

Method used

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  • Application of zerumbone or prodrugs thereof to preparation of calming drugs
  • Application of zerumbone or prodrugs thereof to preparation of calming drugs
  • Application of zerumbone or prodrugs thereof to preparation of calming drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Animal modeling and experimental methods

[0035] The animals were ICR mice, purchased from Beijing Sibeifu Experimental Animal Technology Co., Ltd., and raised in a clean barrier space, weighing 20-24 g.

[0036] The mice were randomly divided into a blank control group, a positive control group, a high-dose group, a middle-dose group and a low-dose group, a total of 5 groups, each with 8 mice. At the same time, the blank control group was given a corresponding volume of distilled water, and the positive control group was given diazepam at a dose of 1.5 mg / kg. The medium-high, medium and low-dose groups of the present invention were given corresponding doses of ginger. Ketones (20mg / kg, 10mg / kg, 5mg / kg at high, medium and low doses respectively), 1 hour after intragastric administration, mice in each group were intraperitoneally injected with sodium pentobarbital at a dose of 40mg / kg, causing Mice sleep.

[0037] During the experiment, the latency and sleep duration of e...

Embodiment 2

[0044] 1. Animal modeling and experimental methods

[0045] The animals were ICR mice, purchased from Beijing Sibeifu Experimental Animal Technology Co., Ltd., and raised in a clean barrier space, weighing 20-24 g.

[0046] The mice were randomly divided into a blank control group, a positive control group, a low-dose group, a middle-dose group and a high-dose group, a total of 5 groups, each with 8 mice. At the same time, the blank control group was given a corresponding volume of distilled water, and the positive control group was given diazepam at a dose of 1.5 mg / kg. The low-dose, medium and high-dose groups of the present invention were given corresponding doses of ginger. Ketone (low, medium and high doses are 5mg / kg, 10mg / kg, 20mg / kg, respectively). After intragastric administration for 1 hour, the mice are placed in the autonomous activity tester for 2 minutes, and the mice’s activity within 5 minutes is recorded Number of activities.

[0047] 2. Statistical methods

[0048]...

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Abstract

The invention discloses an application of zerumbone or prodrugs thereof to preparation of calming drugs. The zerumbones have the structure as shown in formula (I) (as shown in the description).

Description

Technical field [0001] The present invention relates to the use of Zingerone or its prodrug for preparing sedative drugs. Background technique [0002] Terpenes (terpenes) contain oxygen and have (C 5 H 8 ) n Derivatives with different degrees of saturation of the general formula can generally be divided into monoterpenes, sesquiterpenes, diterpenes, etc., and are widely used in preparations with expectorant and cough relieving, expelling wind and sweating, repelling insects and analgesics, and resisting many types During the production of drugs such as tumors. Since terpenoids are mostly obtained from the flowers, fruits, leaves, stems and roots of plants, they have the characteristics of wide and easy availability of raw materials, low cost, safe administration and small side effects. [0003] Zingosterone was first isolated from Zingiber officinale in Southeast Asia in 1960. CN104606176B discloses the extraction of a variety of monocyclic sesquiterpene ketone compounds includi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P25/20
CPCA61K31/122A61P25/20
Inventor 柴兴云屠鹏飞陈苏依勒沙娜·吾肯刘春生李俊俊焦顺刚高小力
Owner BEIJING UNIV OF CHINESE MEDICINE
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