An atmospheric pollution binary mixture health risk evaluation method

Abstract

A novel atmospheric pollution binary mixture health risk evaluation method comprises the following steps: obtaining atmospheric pollutant concentration from literature or actual environment monitoring, selecting pollutants with approximate concentration as binary mixed components to be evaluated, and converting the actual environment exposure concentration into in-vitro equivalent concentration; Obtaining transcriptome data of each pollutant and in-vitro biological test information of a specific path from a public database or literature, calculating a mixed effect value of the transcriptome data and the in-vitro biological test information, and correcting a relative efficacy factor and a combined toxicity action mode; Monte Carlo simulation is carried out on the equivalent concentration invitro of the pollutants, relative efficiency factors are coupled and corrected, and the health risk of the mixed pollutants is evaluated. The method is established on the basis of the environmental exposure concentration and the biological test data of the pollutant monomer, can evaluate the health risk of the pollutant monomer without depending on the mixture toxicity data, saves the manpower and material resource cost, and has a wide application prospect in the fields of practical environmental hybrid exposure health risk evaluation, environmental safety evaluation and the like.

Description

technical field [0001] The invention relates to the technical field of health risk assessment of mixed exposure to pollution, and more particularly to a method for health risk assessment of binary mixtures of air pollution. Background technique [0002] The problem of environmental pollution has never been just a single chemical pollution problem. A wide variety of pollutants in the real environment often exist in mixed forms, and exposure to the human population produces joint toxic effects. Due to the complex and variable health effects produced by the joint action of mixed pollution, the calculation and evaluation of joint toxicity and its health risks have always been the difficulty and focus of the scientific community. As early as 2013, the National Institute of Environmental Health Sciences (NIEHS) pointed out that elucidating the health effects of environmental mixtures should be one of its future research priorities. Atmospheric fine particulate matter (Fine Parti...

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Problems solved by technology

[0004] To sum up, the toxicity prediction method of a single compound has gradually matured and has been widely used in environmental chemical risk assessment, while the complex joint toxic effects of mixed chemicals are difficult problems in environmental toxicology research. Experimental evaluation methods need to be developed

However, due to the limitation of joint toxicity research methods, the health risk assessment of air pollution mixtures is still limited to the working assumption of the simple addition of the toxicity of pollution components, and it is difficult to avoid the problems caused by risk underestimation.

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