Artificial saliva for oral tobacco research and preparation method and application thereof
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A technology for artificial saliva and snus, which is applied in the field of artificial saliva and its preparation for snus research, and can solve the problems of inaccurate results, inconvenient collection and storage, and affecting the quality evaluation of snus.
Inactive Publication Date: 2019-04-09
TOBACCO RES INST CHIN AGRI SCI ACAD
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However, because it is extremely inconvenient to collect and preserve a large amount of real saliva, artificial saliva is used instead of real saliva in the above studies; most of the existing artificial saliva is the inorganic salt type artificial saliva of ISO standard
However, when using the ISO standard inorganic salt type artificial saliva to study snus, the measured nicotine content of snus is higher than the measured value of real saliva, and the results are inaccurate, which affects the quality evaluation of snus
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[0026] The present invention also provides the preparation method of the artificial saliva described in the above technical scheme, comprising the following steps:
[0027] (1) Weigh NaCl, KCl, CaCl 2 2H 2 O, NaH 2 PO 4 2H 2 O, Na 2 S·2H 2 O, urea, carboxymethylcellulose and water are mixed, and concentrated hydrochloric acid is added to obtain pre-artificial saliva;
[0028] (2) Using sodium hydroxide to adjust the pH value of the pre-artificial saliva to 7.0 to obtain artificial saliva.
[0029] The present invention weighs NaCl, KCl, CaCl 2 2H 2 O, NaH 2 PO 4 2H 2 O, Na 2 S·2H 2 O, urea, carboxymethyl cellulose and water are mixed, and concentrated hydrochloric acid is added to obtain pre-artificial saliva.
[0030] The present invention is to described NaCl, KCl, CaCl 2 2H 2 O, NaH 2 PO 4 2H 2 O, Na 2 S·2H 2 The order of adding O, urea, carboxymethyl cellulose and water is not particularly limited, and any order of addition can be adopted. In the pres...
Embodiment 1
[0038] An artificial saliva for snus research, the artificial saliva is prepared from an aqueous solution comprising the following mass concentration components: NaCl 0.4g / L, KCl 0.4g / L, CaCl 2 2H 2 O 0.795g / L, NaH 2 PO 4 2H 2 O 0.78g / L, Na 2 S·2H 2 O 0.005g / L, urea 1g / L, carmellose 3g / L; The water used in the aqueous solution is deionized water, and the pH value of the artificial saliva is 7.0; named after the artificial saliva containing carboxymethyl cellulose .
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Abstract
The invention provides artificial saliva for an oral tobacco research and a preparation method thereof, and belongs to the technical field of artificial saliva preparation. The artificial saliva of the invention is prepared from an aqueous solution comprising the following mass concentration components: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2.2H2O 0.7791~0.8109g/L, NaH2PO4.2H2O 0.7644~0.7956g/L, Na2S.2H2O 0.0049~0.0051g/L, urea 0.98~1.02g/L, carboxymethylcellulose 2.94~3.06g/L, wherein the artificial saliva has a pH of 7.0. The nicotine detection of the oral tobacco form the artificialsaliva of the invention is similar to the artificial saliva. The artificial saliva has good stability and a certain viscosity. The formula has a small variety of ingredients and is a common compound,and has a low cost.
Description
technical field [0001] The invention relates to the technical field of artificial saliva preparation, in particular to an artificial saliva used for snus research and its preparation method and application. Background technique [0002] In China, as a new type of tobacco product, snus in pouches has received more and more attention. It has a special form of use. When using snus, it is placed between the upper gum and upper lip, and through the dissolution of saliva, The components contained in the snus are released into the oral cavity and absorbed by the body. When studying the quality of snus, such as mouthfeel, all need to use saliva. However, because it is extremely inconvenient to collect and preserve a large amount of real saliva, artificial saliva was used instead of real saliva in the above studies; most of the existing artificial saliva is inorganic salt type artificial saliva of ISO standard. However, when using ISO standard inorganic salt type artificial saliva ...
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