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Enteric plant soft capsule and preparation method thereof

A technology of soft capsules and plants, applied in the field of enteric-coated vegetable soft capsules and its preparation, can solve the problems that the disintegration control of enteric-coated vegetable soft capsules needs to be further improved, and achieve the effects of shortening disintegration time, reducing dissolution and accelerating release

Inactive Publication Date: 2019-04-12
JIANGSU ZODIAC MARINE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Enteric-coated vegetable soft capsules can avoid the disadvantages caused by the use of gelatin on the basis of realizing the functions of enteric-coated capsules. Therefore, it has attracted wide attention in recent years, but the disintegration control of enteric-coated vegetable soft capsules needs to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment provides an enteric-coated vegetable soft capsule, which includes a capsule shell, and the capsule shell includes an inner capsule shell and an outer capsule shell. A plurality of supports for the above-mentioned gap.

[0025] The exocyst shell comprises the following raw materials in parts by weight: 50 parts of Tianqing gum, 10 parts of hydroxypropyl cellulose, 15 parts of konjac gum, and 3 parts of acid regulator.

[0026] The inner capsule shell includes the following raw materials in parts by weight: 50 parts of Tianqing gum, 10 parts of hydroxypropyl cellulose, 5 parts of pullulan, 3 parts of modified starch, and 15 parts of konjac gum.

[0027] The raw material composition of the plurality of supports is consistent with the raw material composition of the inner capsule shell, including the following raw materials in parts by weight: 50 parts of Tianqing gum, 10 parts of hydroxypropyl cellulose, 5 parts of pullulan, 3 parts modified starch, 15 par...

Embodiment 2

[0034] This embodiment provides an enteric-coated vegetable soft capsule, which includes a capsule shell, and the capsule shell includes an inner capsule shell and an outer capsule shell. A plurality of supports for the above-mentioned gap.

[0035] The exocyst shell comprises the following raw materials in parts by weight: 60 parts of Tianqing gum, 12 parts of hydroxypropyl cellulose, 18 parts of konjac gum, and 1 part of acid regulator.

[0036] The inner capsule shell includes the following raw materials in parts by weight: 60 parts of Tianqing gum, 12 parts of hydroxypropyl cellulose, 7 parts of pullulan, 5 parts of modified starch, and 18 parts of konjac gum.

[0037] The raw material composition of the plurality of supports is consistent with the raw material composition of the inner capsule shell, which includes the following raw materials in parts by weight: 60 parts of Tianqing gum, 12 parts of hydroxypropyl cellulose, 7 parts of pullulan, 5 parts of modified starch,...

Embodiment 3

[0044] This embodiment provides an enteric-coated vegetable soft capsule, which includes a capsule shell, and the capsule shell includes an inner capsule shell and an outer capsule shell. A plurality of supports for the above-mentioned gap.

[0045] The exocyst shell comprises the following raw materials in parts by weight: 70 parts of Tianqing gum, 15 parts of hydroxypropyl cellulose, 20 parts of konjac gum, and 5 parts of acid regulator.

[0046] The inner capsule shell includes the following raw materials in parts by weight: 70 parts of Tianqing gum, 15 parts of hydroxypropyl cellulose, 8 parts of pullulan, 6 parts of modified starch, and 20 parts of konjac gum.

[0047] The raw material composition of the plurality of supports is consistent with the raw material composition of the inner capsule shell, including the following raw materials in parts by weight: 70 parts of Tianqing gum, 15 parts of hydroxypropyl cellulose, 8 parts of pullulan, 6 parts of modified starch, 20 ...

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Abstract

The present invention relates to an enteric plant soft capsule and a preparation method thereof. The enteric plant soft capsule comprises a capsule shell, the capsule shell comprises an inner capsuleshell and an outer capsule shell, the inner capsule shell and the outer capsule shell are in a gap arrangement, the gap is provided with a plurality of support bodies for maintaining the gap; the outer capsule shell comprises the following raw materials in parts by weight: 50-70 parts of sesbania gum, 10-15 parts of hydroxypropyl cellulose, 15-20 parts of konjac gum and 1-5 parts of an acid mediator; and the inner capsule shell comprises the following raw materials in parts by weight: 50-70 parts of sesbania gum, 10-15 parts of hydroxypropyl cellulose, 5-8 parts of pullulan, 3-6 parts of starch and 15-20 parts of konjac gum. The preparation method can well control decomposition of the outer capsule shell in gastric juice, prevents a filler in the inner capsule shell from being decomposed due to dissolving out, and at the same time reduces dissolving-out of content caused by capsule shell damages, and the capsule has greater softness.

Description

technical field [0001] The invention relates to the technical field of enteric-coated capsules, in particular to an enteric-coated vegetable soft capsule and a preparation method thereof. Background technique [0002] Vegetable soft capsule is a kind of soft capsule made of plant cellulose or water-soluble polysaccharide derived from natural plants, which is made by wrapping and sealing medicine. Effectively avoid the spread of mad cow disease and the occurrence of poisonous capsule incidents, and can meet the requirements of vegetarians. [0003] Enteric-coated capsules are capsules that can disintegrate and release drugs in the small intestine, and are generally used as drug packaging materials that damage the stomach. The existing enteric-coated capsules are mostly made of gelatin and enteric-coated materials, which can prevent the capsule from disintegrating in the acidic environment of the stomach, and can enter the small intestine with the emptying of the stomach, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36
CPCA61K9/4808A61K9/4816
Inventor 聂毅宗有田
Owner JIANGSU ZODIAC MARINE BIOTECH
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