Antibacterial dressing for chemotherapy of skin cancer and preparation method thereof

Abstract

The invention discloses an antibacterial dressing for chemotherapy of skin cancer and a preparation method thereof. The preparation method comprises the steps of (1) dissolving an amino-modified Pluronic F127 drug-carried micelle in water to prepare a solution with the concentration of 2-6 wt%, and uniformly stirring the solution; (2) adding water to dissolve quaternized polyglutamic acid and adding tyramine hydrochloride to prepare a polyglutamic acid solution with the concentration of 15-20 wt%; (3) uniformly mixing the solutions obtained in steps (1) and (2), and then adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, stirring the mixture, pouring the mixture into a mold, and conducting demolding 2-5 minutes later to obtain the antibacterial dressing for the chemotherapy of skin cancer. The prepared antibacterial dressing for the chemotherapy of skin cancer has an ideal uniform network structure, high self-healing efficiency, great broad-spectrum antibacterial property and good wound infection prevention performance and can be used for repairing wounds after a physical resection operation of skin cancer, inhibiting infiltrating tumor tissues which cannot be resected and preventing relapse.

Description

Technical field [0001] The invention belongs to the technical field of biomedical material preparation, and specifically relates to a dressing for antibacterial skin cancer chemotherapy and a preparation method thereof. Background technique [0002] In recent years, the number of skin cancer patients has continued to increase. About 5 million people worldwide are diagnosed with skin cancer every year. There is 1 skin cancer patient in every 5 people in the United States, and the prevalence is increasing year by year. Tumors located on the superficial skin are usually surgically removed, but for infiltrating tumors, it is often difficult to remove cleanly and recur easily after surgery, leading to treatment failure. In addition, notched surgical wounds are prone to infection during the repair process, and the scar tissue after healing is too tight, which affects the patient's appearance. [0003] As a kind of gel material with water as the dispersion medium, hydrogel is formed by c...

AI Technical Summary

Problems solved by technology

Moreover, most of the drugs clinically used for the treatment of skin cancer are fat-soluble and cannot be continuously dispersed in the hydrogel matrix.