Antibacterial dressing for chemotherapy of skin cancer and preparation method thereof

A skin cancer and skin technology, applied in medical science, bandages, etc., can solve the problems of continuous dispersion, improve recovery efficiency, obtain materials easily, and inhibit wound infection

Active Publication Date: 2019-05-10
四川维思达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, most of the drugs clinically used for the treatment of skin cancer are fat-soluble and cannot be continuously dispersed in the hydrogel matrix.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelle particles

[0030] a. Under room temperature conditions, 100mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 10mg of the drug are dissolved in 5ml of acetonitrile solution, and then magnetically stirred at a speed of 100-200r / min for 30min, the drug is an anti-skin cancer fat-soluble drug;

[0031] b. Rotary evaporate the solution obtained in step a, the pressure is 0.06MPa, the temperature of the rotary evaporator is 25℃, the speed is 300r / min, and the film is formed after 30min;

[0032] c. Heat the drug film obtained in b at 40°C, wait for it to become a gel state, add 5ml of physiological saline at the same temperature, fully hydrate and stir well, freeze-dry to obtain powdered aminated F127 drug-loaded micelle particles;

[0033] (2) Preparation of quaternized polyglutamic acid

[0034] ①. Dissolve 1.47g polyglutamic acid and 0.1g acetylhydrazine trimethylammonium chloride in 15ml physiological s...

Embodiment 2

[0040] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelle particles

[0041] a. Under room temperature conditions, 150mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 15mg of the drug are dissolved in 7.5ml of acetonitrile solution, and then magnetically stirred at a rotation speed of 100-200r / min for 30min, the drug is an anti-skin cancer fat-soluble drug;

[0042] b. Rotary evaporate the solution obtained in step a, the pressure is 0.065MPa, the rotating temperature is 28°C, the rotating speed is 300r / min, and the film is formed after 30min;

[0043] c. Heat the drug film obtained in b at 45℃, wait for it to form a gel state, add 7.5ml physiological saline at the same temperature, fully hydrate and stir evenly, freeze-dry to obtain powdered aminated Pluronic F127 drug-loaded micelle particles ;

[0044] (2) Preparation of quaternized polyglutamic acid

[0045] ①. Dissolve 1.47g polyglutamic acid and 0.15g acetylhydrazine trimethylammonium chloride in 15ml...

Embodiment 3

[0051] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelle particles

[0052] a. Put 200mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 20mg of the drug were dissolved in 10ml of acetonitrile solution, and then magnetically stirred at a rotation speed of 100-200r / min for 30min, the drug is an anti-skin cancer fat-soluble drug;

[0053] b. Rotary evaporate the solution obtained in step a, the pressure is 0.07MPa, the rotating temperature is 32°C, the rotating speed is 300r / min, and the film is formed after 30min;

[0054] c. Heat the drug film obtained in b at 50°C, wait for it to become a gel state, add 10ml of physiological saline at the same temperature, fully hydrate and stir well, freeze-dry to obtain powdered aminated Pluronic F127 drug-loaded micellar particles;

[0055] (2) Preparation of quaternized polyglutamic acid

[0056] ①. Dissolve 1.47g polyglutamic acid and 0.2g acetylhydrazine trimethylammonium chloride in 15ml physiological saline, stir at ...

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PUM

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Abstract

The invention discloses an antibacterial dressing for chemotherapy of skin cancer and a preparation method thereof. The preparation method comprises the steps of (1) dissolving an amino-modified Pluronic F127 drug-carried micelle in water to prepare a solution with the concentration of 2-6 wt%, and uniformly stirring the solution; (2) adding water to dissolve quaternized polyglutamic acid and adding tyramine hydrochloride to prepare a polyglutamic acid solution with the concentration of 15-20 wt%; (3) uniformly mixing the solutions obtained in steps (1) and (2), and then adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, stirring the mixture, pouring the mixture into a mold, and conducting demolding 2-5 minutes later to obtain the antibacterial dressing for the chemotherapy of skin cancer. The prepared antibacterial dressing for the chemotherapy of skin cancer has an ideal uniform network structure, high self-healing efficiency, great broad-spectrum antibacterial property and good wound infection prevention performance and can be used for repairing wounds after a physical resection operation of skin cancer, inhibiting infiltrating tumor tissues which cannot be resected and preventing relapse.

Description

Technical field [0001] The invention belongs to the technical field of biomedical material preparation, and specifically relates to a dressing for antibacterial skin cancer chemotherapy and a preparation method thereof. Background technique [0002] In recent years, the number of skin cancer patients has continued to increase. About 5 million people worldwide are diagnosed with skin cancer every year. There is 1 skin cancer patient in every 5 people in the United States, and the prevalence is increasing year by year. Tumors located on the superficial skin are usually surgically removed, but for infiltrating tumors, it is often difficult to remove cleanly and recur easily after surgery, leading to treatment failure. In addition, notched surgical wounds are prone to infection during the repair process, and the scar tissue after healing is too tight, which affects the patient's appearance. [0003] As a kind of gel material with water as the dispersion medium, hydrogel is formed by c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08G69/48
Inventor 汪建新徐啟真陈太军王莹莹左莹莹翁杰冯波段可周宗国冯敬杨启远
Owner 四川维思达医疗器械有限公司
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