Methotrexate dosage regimen determining method, device, storage medium and equipment

A technology of methotrexate and a dosing regimen, applied in the medical field, can solve the problems of poor correlation, inability to accurately judge the drug efficacy information of the dosing regimen MTX, unreasonable, etc., and achieve accurate dosing and scientific and reasonable dosing regimens. Effect

Active Publication Date: 2019-05-14
余鹏
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Problems solved by technology

However, due to the poor correlation between intracellular MTX-PGs concentration and MTX blood drug concentration, determining the dosing regimen only based on the MTX blood drug concentration cannot accurately determine the MTX drug efficacy information corresponding to the dosing regimen. Therefore, the prior art There is some irrationality in the methotrexate dosage regimen in

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  • Methotrexate dosage regimen determining method, device, storage medium and equipment
  • Methotrexate dosage regimen determining method, device, storage medium and equipment
  • Methotrexate dosage regimen determining method, device, storage medium and equipment

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Embodiment Construction

[0044] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0045] In one embodiment, such as figure 1 As shown, a method for determining the dosage regimen of methotrexate is provided, and the method is applied to a processor capable of determining the dosage regimen of methotrexate for explanation. The method includes the following steps:

[0046] Step S110, obtaining the expression of folyl polyglutamic acid synthetase and γ-glutamyl hydrolase in the target patient;

[0047] After the drug (methotrexate) enters the patient's body, it needs to undergo drug metabolism to exert its corresponding drug effect. Drug metabolism refer...

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Abstract

The invention relates to a methotrexate dosage regimen determining method, a device, a storage medium and equipment. Through establishing a methotrexate inner metabolism dynamics model, in consideration of influence of different methotrexate metabolism related enzymes (folypolyglutamate synthetase and gamma-gamma-glutamyl hydrolase) contents to the methotrexate metabolism speed parameter, and thenthe metabolism condition of the methotrexate is simulated through the model, thereby determining the corresponding dosage regimen according to the methotrexate metabolism simulation condition, namelydetermining the dosage regimen according to the methotrexate metabolism related enzyme content differences between different patient individuals, thereby realizing more scientific and reasonable methotrexate dosage regimen, and realizing accurate medicament dispensing for aiming at different patient individuals.

Description

technical field [0001] The present application relates to the field of medical technology, in particular to a method, device, storage medium and equipment for determining a methotrexate dosage regimen. Background technique [0002] Methotrexate (Methotrexate, MTX) is a drug used in the clinical treatment of acute lymphoblastic leukemia, malignant lymphoma, osteosarcoma and other diseases. After MTX enters cells, intracellular MTX is synthesized in folyl polyglutamic acid Under the action of the enzyme (folyl-polyglutamate synthetase, FPGS), glutamic acid (PG) is connected one by one to form the main active ingredient polyglutamic acid methotrexate (MTX-PGs, 2-7). MTX-PGs pass the competitive Inhibit intracellular dihydrofolate reductase (DHFR) to block folic acid metabolism pathway, thereby playing a role in apoptosis of cancer cells. [0003] In the prior art, when determining the dosage of MTX for a patient, the general clinical dosage is used, and then the dosing regimen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10G16B5/00
Inventor 余鹏李欢欢孟凡奇蒋蕾任艺
Owner 余鹏
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