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Inosine tablets preparation method

A kind of inosine tablet and technology of inosine, applied in the field of preparation of inosine tablet

Inactive Publication Date: 2019-06-25
青岛冠龙生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and it is safe for the human body. However, starch is used alone as an excipient. There is no report on the production of inosine freeze-dried tablets by freeze-drying process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription 1000 tablets

[0025] Inosine 195g

[0026] Starch 115g

[0027] Sucrose 80g

[0028] Purified water 1000ml.

[0029] 1) Weigh 115g of jade starch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution between 5-7.5, then heat to 72°C, keep it warm for 120 minutes, and make 5-15% (W / V) cornstarch solution.

[0030] 2) Measure 45ml of purified water, boil it, add 80g of sucrose, stir, dissolve, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion with the filtrate, let cool, add an appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0031] 3) Mix the solution obtained in step A with the solution obtained in step B, stir thoroughly for 30 minutes, and lower to normal temperature to obtain a corn-sucrose solution.

[0032] 4) Weigh 195g of inosine, add it to 1L corn-sucrose s...

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Abstract

The invention discloses an inosine tablets preparation method. The method adopts a freeze-drying processes by two-time cooling and two-time heating, two-time cooling and two-time heating can realize better tablet formability, which improves the dissolution rate of the tablets and improves the bioavailability of the tablets; The tablet overcomes the shortcomings of common inosine tablets, reduces the types and dosages of excipients in the inosine tablets, and has high dissolution rate and high bioavailability, which ensures the efficacy and safety of clinical drugs.

Description

technical field [0001] The invention relates to the field of medicine and production technology, and specifically designs a preparation method of inosine tablets. Background technique [0002] Inosine is a component of ATP, cofactor A, ribonucleic acid and deoxyribonucleic acid in the body, and participates in the material metabolism and energy metabolism of the body. It can increase the level of ATP in the body, can be converted into a variety of nucleotides, and participate in protein synthesis. [0003] Ordinary inosine tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the second volume of inosine tablets in the Chinese Pharmacopoeia (2010 edition), Quality standard, the dissolution rate of inosine tablets reaches more than 80% in 30 minutes is qualified, and more and more studies have shown that the toxic and side effects of the excipients themselves, the incompa...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/26A61K31/7076A61P3/00
Inventor 刘乃山王会会
Owner 青岛冠龙生物制药有限公司
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