Preparation method of nitidine chloride

A kind of chlorinated edematine, reaction technology, applied in the field of medicine, can solve the problems of low total yield, low efficiency, poor water solubility, etc., and achieve the effect of simple synthesis route

Inactive Publication Date: 2019-06-28
YUNNAN MINZU UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total yield is between 0.003% and 0.07%. Due to its poor water solubility, the efficiency of large-scale industrial extraction and production is low and the cost is high, and the total yield obtained by its total synthesis is not high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of nitidine chloride

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0011] The preparation method of the chlorinated dimethicone of the present invention uses azabenzobornene and 4,5-dimethoxy-2-(methoxycarbonyl)phenylboronic acid as reaction raw materials, and undergoes a simple five-step reaction. The synthesis obtains chlorinated acetine, and its synthetic route is as follows:

[0012] .

[0013] The preparation method of described chlorinated acetine comprises the following steps:

[0014] 1) Azabenzobornene and 4,5-dimethoxy-2-(methoxycarbonyl)phenylboronic acid are used as raw materials for the reaction, and palladium acetate is used as the catalyst to obtain intermediate 1;

[0015] 2) Dissolving intermediate 1 in an organic solvent and adding trifluoroacetic acid or trifluoromethanesulfonic acid to react to obtain intermediate 2;

[0016] 3) Reaction of intermediate 2 with methyl iodide to obtain intermediate 3;

[0017] 4) Intermediate 4 is obtained by oxidation of intermediate 3;

[0018] 5) The intermediate 4 was reduced and d...

Embodiment 1

[0027] 1) Synthesis of Intermediate 1

[0028] Azabenzobornene (1 eq.) and 4,5- Dimethoxy-2-(methoxycarbonyl)phenylboronic acid (2-4 equivalents) was reacted at room temperature for 1 hour, and the reaction solution was detected by TLC. The solvent was evaporated to dryness under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain Intermediate 1, a white solid, with a yield of 90%. 1 H NMR (400 MHz, CDCl 3 ) δ 7.22 (s, 1H), 7.13 (s, 1H), 6.72 (s, 1H), 6.65(s, 1H), 6.55 (t, J = 9.2 Hz, 1H), 6.02 (dd, J = 9.6, 4.8 Hz, 1H), 5.92 (d, J = 8.5 Hz, 2H), 5.18 (dd, J = 9.6, 7.6 Hz, 1H), 4.53 (d, J = 10.1 Hz, 1H),3.93 (s, 3H), 3.84 - 3.74 (m, 1H), 3.70 (s, 3H), 3.65 (s, 3H), 1.38 (s, 9H). 13 C NMR (CDCl 3 , 100 MHz): δ 168.1, 155.3, 147.3, 146.9, 137.8, 129.1, 128.5,128.4, 128.1, 127.4, 127.2, 107.1, 101.0, 79.4, 60.4, 56.1, 55.7, 52.4, 51.5,44.8, 28.4, 21.1, 14.2.

[0029] 2) Synthesis of Intermediate 2

[0030] Dissolve Intermed...

Embodiment 2

[0038] Repeat the method of embodiment 1, just make the following modifications:

[0039] 1 Change the chloroform in steps 3 and 4 to dichloromethane;

[0040] 2 Quench the reaction with wet tetrahydrofuran in step 5;

[0041] The product total yield that this implementation makes is 70%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method of nitidine chloride. The method comprises the following steps of 1) catalyzing 4,5-dimethoxy-2-(methoxycarbonyl) phenylboronic acid to react with azobenzene bornene to obtain an intermediate 1 by using a metal palladium/ligand; 2) dissolving the intermediate 1 with an organic solvent, then adding trifluoroacetic acid, and conducting a room temperaturereaction to obtain an intermediate 2; 3) methylating the intermediate 2, oxidizing, reducing, and treating with hydrochloric acid to obtain the nitidine chloride. The synthetic route of the method issimpler, and the total synthesis yield of the nitidine chloride is as high as 72% or more.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of amphetine chloride. Background technique [0002] LMZ is a plant of the genus Zanthoxylum Rutaceae, which is mainly distributed in southern provinces such as Guangxi, Yunnan, Guangdong, and Fujian in my country. Nitidine is an extract of the dried roots of traditional Chinese medicine LMZ, which has various physiological activities such as promoting blood circulation, relieving pain, anti-inflammatory and anti-tumor, and can be used to treat bruises, snake bites, toothache, lymphadenitis, malaria and tumors and many other diseases. [0003] [0004] double-sided needle base [0005] At present, chlorinated cinnamon is mainly extracted and separated from different plants of the genus Zanthoxylum, and the methods used to extract alkaloids are also applicable to chlorinated chlorinated, mainly including reflux method, enzymatic method, ultr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/056
Inventor 周永云樊保敏陈景超樊瑞峰孙蔚青曾广智尹俊林林成源李思达
Owner YUNNAN MINZU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap