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Pharmaceutical composition for treating intractable epilepsy and application thereof

A technology for refractory epilepsy and composition, applied in the field of chemical pharmaceutical compositions, can solve problems such as treatment of epilepsy patients that are not reported in literature, achieve significant social and economic significance, increase dependence, and reduce toxic and side effects.

Active Publication Date: 2019-07-05
AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report that ethambutol hydrochloride can be used for anti-epileptic, and there is no literature report that low-dose ethambutol hydrochloride combined with sodium valproate is used in the treatment of patients with refractory epilepsy.

Method used

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  • Pharmaceutical composition for treating intractable epilepsy and application thereof
  • Pharmaceutical composition for treating intractable epilepsy and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1: Observation of the curative effect of ethambutol hydrochloride combined with sodium valproate on rats with intractable epilepsy

[0016] Healthy male SD rats with body weight in the range of 18-22g. After the experiment started, the lithium chloride-pilocarpine hydrochloride refractory epilepsy model was established first, and the method was as follows: intraperitoneal injection of lithium chloride 120 mg / kg, 20 hours later injection of atropine 1 mg / kg, 30 minutes later intraperitoneal injection of pilocarpine 50 mg / kg. If status epilepticus does not appear, continue intraperitoneal injection of 10 mg / kg of pilocarpine every 30 minutes until rats develop grade 4-5 epilepsy and status epilepticus occurs for 60 minutes, and intraperitoneal injection of 300 mg / kg of chloral hydrate terminates the seizure.

[0017] The acute phase of epileptic seizures was maintained for 24 hours, and then a latent period of about two weeks began. During this period, 5% glucos...

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Abstract

The invention discloses a pharmaceutical composition for treating intractable epilepsy and application thereof. The active components of the pharmaceutical composition comprise sodium valproate or divalproex sodium and ethambutol or medicinal salt thereof. The pharmaceutical composition has the advantages that the fact that low-dose ethambutol hydrochloride has an anti-epileptic effect is discovered for the first time, the ethambutol hydrochloride is combined with the sodium valproate or divalproex sodium to treat the intractable epilepsy, the pharmaceutical composition is evident in anti-epileptic effect, and the toxic and side effects of the pharmaceutical composition are lowered evidently.

Description

technical field [0001] The invention relates to a chemical drug composition, more specifically, to a western medicine composition for treating refractory epilepsy and its application, belonging to the technical field of medicine. Background technique [0002] Epilepsy is a common neurological disease. It is a syndrome of chronic recurrent transient brain dysfunction, characterized by seizures caused by abnormal discharge of brain neurons. Among them, more than 30% of epilepsy patients are difficult to control their seizures with commonly used antiepileptic drugs in clinical practice, which is called intractable epilepsy. The pathogenesis of epilepsy is very complicated, and its entire mechanism has not been fully understood so far, but some important links of its pathogenesis have been discovered: the electrophysiological basis of epilepsy is highly synchronized abnormal discharge of neurons, and epilepsy is caused by The epileptogenic focus is directly caused by the epilep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/133A61P25/08
CPCA61K31/133A61K31/19A61P25/08A61K2300/00
Inventor 褚旭孙冉闫换李开龙
Owner AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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