Method for predicting and verifying the curative effect of glucocorticoid based on image omics

Abstract

The invention provides a method for predicting and verifying the curative effect of glucocorticoid based on image omics, which comprises the following steps: S1, acquiring an original medical image ofa patient using glucocorticoid to treat connective tissue disease related interstitial pulmonary disease, and dividing the obtained original medical image into a training group and a verification group; s2, performing quantification processing on the original medical image to obtain image omics feature data; s3, establishing a prediction model of the image omics characteristics in the training group, and performing test verification in the verification group; and step S4, determining effective clinical characteristics and image omics characteristic tags adopting glucocorticoid, and performingverification in a verification group. According to the method, the curative effect of glucocorticoid is predicted and verified on the basis of imaging omics so as to identify patients sensitive to glucocorticoid treatment, and a specific reference basis is provided for doctors to diagnose and treat patients with connective tissue related interstitial pulmonary diseases, so that the patients are effectively treated, and the success rate of treatment is increased.

Description

technical field [0001] The invention relates to a method for predicting and verifying the curative effect of glucocorticoids based on radiomics. Background technique [0002] Interstitial lung disease (ILD) is a heterogeneous group of diseases characterized by pulmonary inflammation and / or fibrosis, ranging from idiopathic interstitial pneumonia to secondary interstitial lung disease, including connective tissue disease-related Qualitative lung disease. Interstitial lung disease with fibrosis is usually incurable and is associated with high morbidity and mortality. The treatment of connective tissue disease-associated interstitial lung disease has been controversial and lacks widely accepted supporting evidence. Glucocorticoids, cyclophosphamide, azathioprine, and mycophenolate mofetil are the most extensively studied drugs. Glucocorticoids are widely used in the management of connective tissue disease-associated interstitial lung disease, but there is little evidence fro...

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