Method for efficiently producing melatonin

A high-efficiency technology for melatonin, applied in the field of high-efficiency melatonin production, can solve the problems of low extraction rate of melatonin purity and high production cost, and achieve the effects of reducing production cost, simple operation, and ensuring extraction efficiency

Inactive Publication Date: 2019-09-13
罗田县新普生药业有限公司
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for efficient production of melatonin to solve the problems of low purity extraction rate and high production cost of melatonin proposed in the above background technology

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for efficiently producing melatonin
  • Method for efficiently producing melatonin
  • Method for efficiently producing melatonin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them.

[0021] An embodiment provided by the present invention: a method for efficiently producing melatonin, in terms of material quantity ratio, including 100% of the raw material ratio of 5-methoxyindole, and 100% of the ratio of carbonyl chloride as raw material 98%, the proportion of ammonium hydroxide is 57% of the generated compound, and the proportion of lithium aluminum hydride is 80% of the generated compound.

[0022] Further, include the following steps:

[0023] Step 1: 5-methoxyindole (1) is used as a raw material, and carbonyl chloride reaction solvent is added to oxalylate 5-methoxyindole, thereby reacting to generate compound (2);

[0024]

[0025] Step 2: leave the pre...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for efficiently producing melatonin, relates to the technical field of melatonin synthesis, and aims to solve the problems that purity and an extraction rate of melatonin are relatively low and preparation cost is relatively high in the prior art. According to the method, 5-methoxy indole is taken as 100% of a raw material, carbonyl chloride accounts for 98% of theraw material, ammonium hydroxide accounts for 57% of a generation compound, and lithium aluminum hydride accounts for 80% of the generated compound. The 5-methoxy indole (1) is taken as a raw material, and a carbonyl chloride reaction solvent is added to acylate the 5-methoxy indole, so that a reaction is carried out to generate a compound (2); the generated compound (2) is stranded, and then anammonium hydroxide solvent is mixed with the generated compound (2) according to a certain usage amount to generate a compound (3); and after the compound (3) is generated, a lithium aluminum hydridereagent is added to carry out a reduction reaction on the compound (3) to generate a compound (4).

Description

technical field [0001] The invention relates to the technical field of melatonin synthesis, in particular to a method for efficiently producing melatonin. Background technique [0002] Melatonin is an amine hormone produced by the pineal gland in mammals and humans, which makes a type of melanin-producing cell glow, hence the name melatonin. It exists in many organisms from algae to humans, and the content level changes with the time of day. Melatonin is the first biologically active substance discovered in the pineal gland. When mammals are in the dark, melatonin The secretion activity is immediately strengthened; when it is turned into a bright environment, the secretion stops. The rhythm of melatonin secretion can be measured from urine as the light changes. Other factors such as sleep, diet, mental state, and stress also play a role. Injection of melatonin into the hypothalamus can inhibit the secretion of gonadotropins, but it has also been observed that melatonin ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/14
CPCC07D209/14
Inventor 蔡瑾
Owner 罗田县新普生药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap