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Application of paeoniflorin in inhibition of growth of carbapenem-resistant klebsiella pneumoniae

A technology of Klebsiella pneumoniae and carbapenems is applied in the application field of paeoniflorin in inhibiting the growth of carbapenem-resistant Klebsiella pneumoniae, so as to reduce the fatality rate, have a wide application value, and solve the The effect of drug infection

Inactive Publication Date: 2019-09-20
SHAANXI UNIV OF SCI & TECH
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] Paeoniflorin, as one of the active ingredients of Radix Paeoniae Rubra, has been studied at home and abroad in terms of dilating blood vessels, analgesia, sedation, and anti-inflammatory and anti-ulcer activities, but there is no report on the inhibition of bacterial growth by paeoniflorin

Method used

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  • Application of paeoniflorin in inhibition of growth of carbapenem-resistant klebsiella pneumoniae
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  • Application of paeoniflorin in inhibition of growth of carbapenem-resistant klebsiella pneumoniae

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Embodiment Construction

[0020] Specific examples are given below.

[0021] 1. Drug susceptibility test of human Klebsiella pneumoniae

[0022] In the present invention, 4 strains of human Klebsiella pneumoniae are used as starting strains, and drug sensitivity test strips of two commonly used antibiotics, imipenem and meropenem, are selected for drug sensitivity test.

[0023] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the plate, and place it at room temperature for 3-5 minutes. Use sterile tweezers to stick drug-sensitive paper sheets with a diameter of 6 mm on the surface of the plate as required, and three drug-sensitive sheets of each type are parallel. Place the inoculated plate at 36-37°C and incubate for 18-24 hours. The diameter of the inhibition zone was measured with a vernie...

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Abstract

The invention discloses application of paeoniflorin in inhibition of growth of carbapenem-resistant klebsiella pneumoniae. According to the fact that paeoniflorin has a good in-vitro killing effect on human klebsiella pneumoniae capable of resisting imipenem and meropenem, growth of carbapenem-resistant klebsiella pneumoniae can be inhibited, the minimum bactericidal concentration is 2 mg / mL, and the minimum bacteriostatic concentration is 1.15 mg / mL. The invention provides an inhibitory effect of paeoniflorin on carbapenem-resistant klebsiella pneumoniae. According to the invention, the problem of drug-resistant infection of carbapenem-resistant klebsiella pneumoniae can be effectively relieved or solved, the mortality is reduced, a new idea is provided for inhibiting the human carbapenem-resistant klebsiella pneumoniae, and the method has important practical significance.

Description

technical field [0001] The invention belongs to the technical field of application of active ingredients of traditional Chinese medicines, and relates to the application of paeoniflorin in inhibiting the growth of carbapenem-resistant Klebsiella pneumoniae. Background technique [0002] Klebsiella pneumoniae (Klebsiellapneumoniae, KP) is widely distributed in nature and belongs to one of the subspecies of the genus Klebsiella. It is a common Gram-negative conditional pathogen. The bacteria are facultative anaerobic bacteria, no flagella, no motility. Has a thick capsule. Most strains have pili. Nutritional requirements are not high, and the colonies grown on ordinary culture medium are large, mucus-like, fused with each other, and easily pulled into silk by picking with an inoculation ring. It can cause urinary system infection, respiratory tract and digestive system infection in patients. [0003] In the past ten years, with the continuous increase of the types of new a...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/71A61K36/65A61P31/04A23L33/105
CPCA23V2002/00A61K31/7048A61K36/65A61K36/71A23L33/105A61P31/04A23V2200/30A23V2250/21
Inventor 钱卫东王文静张家宁李鑫辰付玉婷刘淼孙照欢杨敏
Owner SHAANXI UNIV OF SCI & TECH
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