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Carboxymethyl chitosan care solution and preparation method and application thereof

A technology of carboxymethyl chitosan and care solution, which is applied in the field of medical care, can solve problems such as side effects and nasal mucosa damage, and achieve the effect of inhibiting inflammation, inhibiting itching, and achieving healing

Inactive Publication Date: 2019-09-24
上海威尔医疗保健厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics, antihistamines and topical glucocorticoids are often used clinically for rhinitis and pharyngitis in order to achieve the purpose of reducing inflammation and reducing congestion. However, long-term use of antiallergic and hormone drugs is prone to various side effects; Local microwave or laser therapy, surgical treatment, but damage to nasal mucosa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A carboxymethyl chitosan care solution, comprising the following components in mass percentage: 0.3% carboxymethyl chitosan, 0.9% sodium chloride, 0.006% mint, and the balance is distilled water; the carboxymethyl chitosan The 0-carboxymethyl substitution degree of the sugar is not less than 90%, the degree of deacetylation is not less than 65%, and the molecular weight is 800-30,000Da.

[0030] The preparation method of above-mentioned a kind of carboxymethyl chitosan care solution, comprises the following steps:

[0031] Step 1: Heat the distilled water to above 50°C, pour it into a stainless steel tank, weigh the required carboxymethyl chitosan according to 0.3wt%, add it to the above distilled water, and stir evenly at a speed of 400-600r / min , cooled to room temperature.

[0032] Step 2: Add 0.006wt% mint to the solution in the above step 1, and stir evenly at a speed of 400-600r / min.

[0033] Step 3: Add 0.9wt% sodium chloride to the solution in the above step 2...

Embodiment 2

[0037] A carboxymethyl chitosan care solution, comprising the following components in mass percentage: 0.1% carboxymethyl chitosan, seawater, and the remainder being distilled water; the 0-carboxymethyl substitution of the carboxymethyl chitosan The degree of deacetylation is not less than 90%, the degree of deacetylation is not less than 65%, and the molecular weight is 800-30,000Da.

[0038] The preparation method of above-mentioned a kind of carboxymethyl chitosan care solution, comprises the following steps:

[0039] Step 1: Take clean seawater, filter it, add it into distilled water at normal temperature, make the sodium chloride content therein 0.85wt%, stir evenly, and use it as the first component.

[0040] Step 2: Weighing 0.1wt% of the required carboxymethyl chitosan, adding it to the solution of the first component, stirring evenly at a speed of 400-600r / min, as the second component.

[0041] Step 3: Filter and sterilize the solution of the second component, fill i...

Embodiment 3

[0043] A carboxymethyl chitosan care solution, comprising the following components in mass percentage: 0.5% carboxymethyl chitosan, 0.85% sodium chloride, 0.02% sodium pyruvate, 0.02% polyhexamethylene biguanide; The O-carboxymethyl substitution degree of the carboxymethyl chitosan is not less than 90%, the degree of deacetylation is not less than 65%, and the molecular weight is 800-30,000Da.

[0044] The preparation method of above-mentioned a kind of carboxymethyl chitosan care solution, comprises the following steps:

[0045] Step 1: Weighing 0.5wt% carboxymethyl chitosan, adding it into distilled water at room temperature, stirring evenly at a speed of 400-600r / min, as the first component.

[0046] Step 2: Weigh 0.9wt% sodium chloride, 0.02wt% sodium pyruvate, and 0.02wt% polyhexamethylene biguanide and add them to the first component, stir in a stirrer at a constant stirring speed of 500r / min for 20 - 40 minutes, as the second component.

[0047] Step 3: filter and steri...

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Abstract

The invention relates to the field of care and medical instruments, and in particular relates to a carboxymethyl chitosan care solution and a preparation method and application thereof. The carboxymethyl chitosan care solution comprises the following components in mass percent: 0.05%-3.00% of carboxymethyl chitosan, 0.1%-5.0% of an osmotic pressure regulator, 0.005%-0.1% of mint and the balance of distilled water. The carboxymethyl chitosan care solution disclosed by the invention is used for daily auxiliary treatment of nasal cavity, throat, skin care, acute and chronic rhinitis, sinusitis, pharyngitis, skin allergy and skin itching.

Description

technical field [0001] The invention relates to the fields of medical care and medical devices, in particular to a carboxymethyl chitosan care solution. Background technique [0002] In daily life, upper respiratory tract infections, immune reactions, inhaled allergens and irritating air pollutants can all irritate the mucous membranes of the nasal cavity and throat, cause edema and inflammation, and cause allergic rhinitis, sinusitis, and pharyngitis. Antibiotics, antihistamines and topical glucocorticoids are often used clinically for rhinitis and pharyngitis in order to achieve the purpose of reducing inflammation and reducing congestion. However, long-term use of antiallergic and hormone drugs is prone to various side effects; Local microwave or laser therapy, surgical treatment, but damage to the nasal mucosa. As an effective supportive therapy, local irrigation of bilateral nasal cavities has been widely used in the treatment of nasal cavity and sinuses, and has been ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K36/534A61K9/08A61K9/12A61P11/02A61P11/04A61P17/00A61P37/08A61P17/04
CPCA61K9/0014A61K9/0043A61K9/006A61K9/08A61K31/722A61K36/534A61K47/02A61P11/02A61P11/04A61P17/00A61P17/04A61P37/08A61K2300/00
Inventor 唐耀明
Owner 上海威尔医疗保健厂
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