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A kind of Huoxia capsule with antitumor effect

An anti-tumor effect, Huoxia technology, applied in the field of drug preparation, can solve the problems of high toxicity and side effects, unreasonable production process conditions, and poor effect of anti-tumor drugs

Active Publication Date: 2021-06-04
北海市海金花生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a Huoxia Capsule with anti-tumor effect which can effectively inhibit the growth of tumor cells and has low toxic and side effects, and utilize scientific methods to screen the best production process of Huoxia Capsule Conditions, to overcome the shortcomings of current antineoplastic drugs, such as poor effect, large toxic and side effects, low treatment efficiency, and unreasonable production process conditions

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Raw material formula:

[0035] 15kg of Epimedium, 9kg of Prunella vulgaris, 9kg of Bingtangcao, 45kg of Argonaut japonicus;

[0036] 2. Preparation method:

[0037] (1) Raw material extraction: wash and dry 7.8 kg of molybdenum stalks in the above formula, and then grind them into 80-mesh fine powder for later use; add 900 kg of water to the remaining raw materials, soak for 30 minutes, and heat to 60°C under 0.1atm atmospheric pressure Extract under reduced pressure for 2 hours, filter, and obtain the filtrate for later use, carry out the second and third extractions on the residue, add water in the amount of 700 kg for the second and third extractions, soak for 30 minutes in the same way, and heat to 60 Extract under reduced pressure at ℃ for 2 hours, filter to obtain the filtrate, extract three times in total, obtain three times of filtrate, combine the three times of filtrate, move the filtrate to a concentrator, and concentrate under reduced pressure at 0.1atm at...

Embodiment 2

[0043] 1. Raw material formula:

[0044] 21 kg of Epimedium, 15 kg of Prunella vulgaris, 15 kg of Bingtangcao, and 54 kg of Verruca stalk;

[0045] 2. Preparation method:

[0046] (1) Raw material extraction: wash and dry 10.5 kg of molybdenum verruca in the above formula and grind it into 200-mesh fine powder for later use; add 1300 kg of water to the remaining raw materials, soak for 30 minutes, and heat to 60°C under 0.1atm atmospheric pressure Extract under reduced pressure for 2 hours, filter, and obtain the filtrate for later use, carry out the second and third extractions on the residue, add water in the amount of 1000 kg for the second and third extractions, soak for 30 minutes in the same way, and heat to 60 Extract under reduced pressure at ℃ for 2 hours, filter to obtain the filtrate, extract three times in total, obtain three times of filtrate, combine the three times of filtrate, move the filtrate to a concentrator, and concentrate under reduced pressure at 0.1at...

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Abstract

The invention discloses a Huoxia Capsule with anti-tumor effect, which comprises the following raw materials: Epimedium, Prunella vulgaris, Bingtangcao and Moyu stalk, and is prepared by the following method: raw material extraction: take 2.6 of the above formula ‑3.5 parts of Argonaut verruca are washed and dried, crushed into 80-mesh fine powder for later use, and the remaining raw materials are added to water, heated at 0.1atm atmospheric pressure to 60°C and extracted three times under reduced pressure, and the filtrate is concentrated to obtain a thick paste; Huoxia dry paste powder was prepared from taro fine powder and thick ointment; Huoxia granules were prepared into empty capsules with 50% ethanol solution as a wetting agent, and each gram of Huoxia granules was equivalent to 12.5 grams of crude drug. Huoxia Capsules. The present invention verifies that the Huoxia Capsule has inhibitory activity on NCI-H460 cells both in vivo and in vitro, and can induce cell apoptosis through in vitro tumor suppression test and in vivo nude mouse xenograft tumor test. Its mechanism of action may be related to scavenging free radicals and increasing TNF‑ α content, inhibit IL-6 secretion, and increase the expression of Bax and Caspase-3 genes.

Description

technical field [0001] The invention relates to a Huoxia capsule with antitumor effect, which belongs to the technical field of medicine preparation. Background technique [0002] Traditional Chinese medicine is a huge treasure house. The development of Chinese medicine theory has laid a foundation for the treatment of tumors for a long time. Scrofula, goiter, mastitis, carbuncle, lump in the abdomen, phlegm nucleus formed by phlegm coagulation and blood stasis, All are the causes of tumors. Chinese medicine has effective treatment methods and medicines for the above diseases. As we all know, every Chinese herbal medicine contains complex ingredients, ranging from a dozen to hundreds of kinds. Tumor drugs are a direction worthy of efforts. In fact, many drugs prepared from traditional Chinese medicine have played an important role in the treatment of tumors. It is a new exploration for the treatment of tumors by screening traditional Chinese medicines with anti-tumor effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61K9/48A61P35/00
CPCA61K9/16A61K36/296A61K36/536A61K36/808A61K36/888A61K2236/331A61K2236/39A61P35/00A61K2300/00
Inventor 赖德禄
Owner 北海市海金花生物技术有限公司
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