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Combination of polyethylene glycol and sirolimus and application of combination

A technology of rapamycin and polyethylene glycol, applied in the field of medicine, can solve the problems of complex preparation process, wide particle size distribution of nano-carriers, unsatisfactory treatment effect and the like

Pending Publication Date: 2019-10-11
JENKEM TECH CO LTD TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the preparation process of the above-mentioned combination of rapamycin and nanocarriers is complicated, the cost is high, the particle size distribution of nanocarriers is wide, the product batch stability is poor, and the therapeutic effect is not ideal, which is not conducive to industrial scale-up production and practical application.

Method used

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  • Combination of polyethylene glycol and sirolimus and application of combination
  • Combination of polyethylene glycol and sirolimus and application of combination
  • Combination of polyethylene glycol and sirolimus and application of combination

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Embodiment Construction

[0150] Unless otherwise defined, all scientific and technical terms used in the present invention have the same meaning as commonly understood by those skilled in the technical fields to which the present invention relates, such as:

[0151] "Alkyl" refers to a straight or branched hydrocarbon chain free radical without unsaturated bonds, and a C1-C6 alkyl refers to an alkyl group containing 1-6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, etc.; if the alkyl is substituted by cycloalkyl, the corresponding "cycloalkylalkyl" radical, C4-10 cycloalkylalkyl refers to cycloalkylalkyl containing 4-10 carbon atoms, such as cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexyl Methyl, etc.; if the alkyl group is substituted by an aryl group, then it corresponds to an "aralkyl" radical, and the C7-14 aralkyl group refers to an aralkyl group containing 7-14 carbon atoms, such as benzyl, di Ben...

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Abstract

The invention discloses a combination of polyethylene glycol and sirolimus and application of the combination, in particular to application in preparing drugs for reducing immune responses. The combination of polyethylene glycol and sirolimus can significantly reduce the production rate of antibodies for exogenous immunogens and reduce the excessively strong immune responses caused by the application of the combination, and has the advantages that the treatment effect of a treatment agent can be ensured or even improved, the autoimmune condition of a recipient is improved, and the transplantation rejection reactions are reduced or even eliminated; the preparation process of the combination is relatively simple, the cost is low, the industrial production is easily achieved, and the application value is very high.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a combination of polyethylene glycol and rapamycin and its use, especially its use in the preparation of drugs for reducing immune responses, more specifically polyethylene glycol and rapamycin Use of a conjugate of rapamycin in the preparation of a medicament for reducing a recipient's excessive immune response to an exogenous immunogen such as a therapeutic agent, a graft, and the like. Background technique [0002] Immunogenicity refers to the ability to stimulate the body to form specific antibodies or sensitize lymphocytes, that is, antigens can stimulate specific immune cells to activate, proliferate, and differentiate immune cells, and finally produce immune effector substances antibodies and sensitized lymphocytes characteristics. Immune response refers to the physiological process produced by the body's immune system in response to immunogen stimulation for the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/60A61K31/436A61K45/06A61P37/06A61P35/00A61P7/00A61P7/04A61P31/00A61P37/02A61P3/00
CPCA61K47/60A61K31/436A61K45/06A61P37/06A61P35/00A61P7/00A61P7/04A61P31/00A61P37/02A61P3/00A61K2300/00C08G65/48
Inventor 汪进良冯泽旺王雷敏赵宣
Owner JENKEM TECH CO LTD TIANJIN
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