Composition for inhibiting skin cell proliferation and application thereof

A technology of skin cell and skin proliferation, applied in skin diseases, drug combinations, cosmetic preparations, etc., can solve problems such as dandruff that cannot be solved

Pending Publication Date: 2019-12-24
NEW VISION GRP BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For dandruff problems that are not caused by mold, shampoos made with the above ingredients often cannot solve the dandruff problem

Method used

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  • Composition for inhibiting skin cell proliferation and application thereof
  • Composition for inhibiting skin cell proliferation and application thereof
  • Composition for inhibiting skin cell proliferation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Materials and Methods

[0032] (1) Cell lines and cell culture

[0033] This study will use human keratinocytes (HaCaT cells) as the main research object, purchased from ATCC (American Type Culture Collection, USA).

[0034] The human skin keratinocyte strain HaCaT cells were cultured in a humid incubator at 37°C in an environment of 5% carbon dioxide and 95% oxygen in the air, placed in Dulbecco's modified Eagle medium (DMEM), and supplemented with 10% fetal Bovine serum, 100 IU / mL penicillin, 100 μg / mL streptomycin, 2 mM sodium pyruvate and 1% non-essential amino acids (NEAA). The medium was changed every two days. For subculture, after being treated with 0.1% trypsin (Trypsin)-EDTA mixture, the cells were collected and diluted at a ratio of 1:10 for re-cultivation. The cells used in the research were between 12 and 40 passages. 24 hours before drug treatment, cells were seeded and left for 24 hours. The control group was maintained in culture medium and drug sol...

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PUM

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Abstract

The invention discloses a composition for inhibiting skin cell proliferation and an application thereof. The invention relates to a composition for inhibiting skin cell proliferation, which comprisesa combination of selenium sulfide and piroctone olamine, and the composition can be used for preparing a shampoo, a hair care composition, an external preparation or an external medical preparation that inhibits skin cell proliferation but does not produce significant toxicity.

Description

technical field [0001] The invention relates to a composition for inhibiting skin cell proliferation and its application. Background technique [0002] In the commercially available shampoo products advertised as anti-dandruff, the anti-dandruff ingredients are nothing more than the following four functions: 1) reduce dandruff bacteria, 2) cell stabilizer, 3) keratolytic agent and 4) anti-inflammation Anti-itch ingredients. If it is distinguished from a medical point of view, it mainly has the following components: [0003] 1. Zinc Pyrithione (Zinc Pyrithione), it can kill dandruff bacillus and remove aging keratinocytes, inhibiting dandruff production. [0004] 2. Selenium Sulfide is an antifungal agent used to deal with the growth of Bacillus dander. Its mechanism of action comes from the advantage of inhibiting cell division to control the growth of dandruff spores and achieve the effect of removing dandruff. However, after washing, the hair often feels greasy, and ev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K31/4412A61P17/06A61P17/00A61P35/00A61K8/23A61K8/49A61Q5/02A61Q5/12
CPCA61K8/23A61K8/4926A61K31/4412A61K33/04A61K2800/592A61Q5/02A61Q5/12A61P17/00A61P17/06A61P35/00A61K2300/00
Inventor 罗胥恩
Owner NEW VISION GRP BIOTECH LTD
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