High-voltage ultrashort pulse power source for tumor ablation

Abstract

The invention relates to a high-voltage ultrashort pulse power source for tumor ablation. The power source comprises a measurement and control unit, a radio frequency modulator, an isolation transformer, a demodulator and a waveform generator; the first input end of the measurement and control unit is connected to an electrocardiogram detector; the second input end of the measurement and control unit is connected to an electrode needle; the first output end of the measurement and control unit is connected to the input end of the radio frequency modulator; the output end of the radio frequencymodulator is connected to the input end of the demodulator through the isolation transformer; the output end of the demodulator is connected to the electrode needle through the waveform generator; thesecond output end of the measurement and control unit is connected with the demodulator; and the third output end of the measurement and control unit is connected with the waveform generator. According to the high-voltage ultrashort pulse power source for tumor ablation, the isolation transformer is combined with a combined module, so that electrical isolation in the high-voltage ultra-short pulse power source is achieved, and therefore, use safety is improved; multiple output pulses can be independently arranged by configuring multiple circuits, so that outputted high-voltage ultra-short pulses can be modulated, and therefore, the application range of the power source is extended.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a high-voltage ultrashort pulse power supply for tumor ablation. Background technique [0002] High-voltage square-wave pulsed electric field tumor therapy device (nanoknife) is a brand-new cutting-edge tumor ablation device, which uses electric field energy and based on the principle of irreversible electroporation to transmit high-voltage electric field to tumor cells in the form of micropulses to change the cell transmigration. The membrane potential creates nanoscale pores on the lipid bilayer cell membrane, increases the permeability of the cell membrane, causes irreversible electroporation of tumor cells in the target area, and eventually leads to tumor death. Specifically, an electrode needle with a diameter of 1 mm is inserted into the tumor through the skin, and the size and position of the expected electric field are calculated and drawn by computer technology, ...

AI Technical Summary

Problems solved by technology

[0003] At present, the high-voltage ultra-short pulse power supply used for electrode needles is mainly direct discharge type, such as figure 1 As shown, the energy storage capacitor C is connected in parallel at both ends of the power supply V, one end of the energy storage capacitor C is connected to the input terminal of the trigger circuit through the high-voltage power switch Q, and the output terminal of the trigger circuit is connected to the resistor Z L One end of the resistor Z L The other end of is connected to the other end of the energy storage capacitor C, where the resistor Z L It represents the resistance of the human body. The amplitude of the high-voltage ultra-short pulse is determined by the voltage of the power supply V, and the pulse repetition frequency, pulse width and pulse number are determined by the trigger circuit. As a result, the output high-voltage ultra-short pulse cannot be independently set and cannot be directly applied to Ablation of tumors of different shapes or sizes; the direct discharge high-voltage ultra-short pulse power supply mainly uses the high-voltage power switch Q for direct discharge, which is easy to generate the required output waveform, but there is a great potential safety hazard. Once the high-voltage power switch is discharged When Q breaks down, all the energy in the storage capacitor C will be released to the resistor Z L , resulting in medical malpractice

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