Pressure drug delivery device and drug storage core layer

Abstract

The invention relates to a pressure drug delivery device and a drug storage core layer, and is suitable for external and transdermal drug delivery. The pressure drug delivery device comprises a negative-pressure shell. One side of the negative-pressure shell is of an enclosed shell with a negative-pressure air outlet, and the other side of the negative-pressure shell is of an open end. At least one open drug delivery end with one or more recessed drug delivery surfaces on the cross section line, or at least one middle drug delivery plate with one or more recessed drug delivery surfaces on thecross section line, is mounted on the side of the open end of the negative-pressure shell. The drug storage core layer with one or more matched protrusions on the cross section is mounted on the sideof the drug delivery surface. The pressure drug delivery device has the advantages that the surface area of stratum corneum is increased, the thickness is reduced, skin injuries are small, the drug delivery pressure is uniform and high, the drug delivery amount, depth and area are large, the drug delivery distribution is uniform, there is a step-by-step drug delivery process based on infiltration,requirements on the size of delivered particles are low, the dosage form range is wide, the cost is low, and operations are simplified.

Description

technical field [0001] The invention relates to a pressure drug delivery device and a drug storage core layer, which are suitable for external application and percutaneous drug delivery. Background technique [0002] Traditional external application and transdermal drug delivery methods are common external application, microneedle external application and microneedle injection. Although common external application is low in cost and easy to operate, its absorption efficiency is not high, the bioavailability of the drug is not high, and the therapeutic index of the drug is not high; Although microneedle external application and microneedle injection have improved absorption efficiency, drug bioavailability, and drug therapeutic index, they are costly, complicated to operate, generally uniform in drug distribution, and cause damage to the stratum corneum. Contents of the invention [0003] The object of the present invention is to provide a method that can increase the surfa...

AI Technical Summary

Problems solved by technology

[0002] Traditional external application and transdermal drug delivery methods are common external application, microneedle external application and microneedle injection. Although common external application is low in cost and easy to operate, its absorption efficiency is not high, the bioavailability of the drug is not high, and the therapeutic index of the drug is not high; Although microneedle external application and microneedle injection have improved absorption efficiency, drug bioavailability, and therapeutic index of drugs, they are costly, complicated to operate, generally uniform in drug distribution, and cause damage to the stratum corneum

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