Application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss

An inflammatory and bone loss technology, applied in drug combinations, peptide/protein components, bone diseases, etc., can solve unseen problems and achieve the effect of protecting inflammatory bone loss

Active Publication Date: 2020-03-17
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss
  • Application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss
  • Application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss

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[0023] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0024] RAW264.7 is a mouse mononuclear macrophage cell line and BMMs are primary mouse mononuclear macrophages, which can differentiate into osteoclasts under the stimulation of RANKL and M-CSF, and are ideal for studying osteoclast differentiation and fusion Commonly used cell models for biological behaviors such as , maturation, and osteophagy. At the same time, osteoclasts are closely related and coupled with osteoblasts, bone cells, and stromal cells, and are important regulatory elements for bone matrix dynamic balance and electrolyte homeostasis in vivo. Inflammatory bone loss is often caused by excessive bone resorption caused by the release of excessive inflammatory factors, which is the result of excessive activation of osteoclasts. Therefore, RAW264.7 and BMM were selected as cell models to study the effects of recombinant IFN-λ1...

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Abstract

The invention relates to application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss, thereby solving a problem of bone metabolism imbalance caused by overactive osteoclasts triggered by release of a large number of inflammatory factors in a serious inflammatory bone loss state caused by bone infection. The applicant findsthat the recombinant IFN-lambda 1 protein can regulate and control the osteoclast differentiation and fusion process and reduce inflammatory factor release in the osteoclast differentiation process through experimental exploration, thereby solving a problem that osteoclasts are excessively activated in an inflammatory state and thus realizing the effect of protecting inflammatory bone loss.

Description

technical field [0001] The invention belongs to the technical field of orthopedic biological control and relates to the application of recombinant IFN-λ1 protein in the preparation of drugs for preventing and treating inflammatory bone loss. Background technique [0002] Bone infection is one of the most common and serious complications of fractures and orthopedic surgery. It has always troubled clinicians because of the limitations of its understanding and treatment methods. Staphylococcus aureus is the main pathogen, accounting for about 65% to 70% of the pathogenic bacteria detected in traumatic osteomyelitis. Bone infection often leads to excessive inflammatory bone destruction, nonunion, resulting in fracture nonunion or delayed union. Osteoblasts and osteoclasts are the main cells involved in bone remodeling, and they work together to maintain the dynamic balance of bone tissue. In an infected state, acute and chronic inflammatory stimuli can alter this homeostasis a...

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Application Information

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IPC IPC(8): A61K38/21A61P19/08
CPCA61K38/217A61P19/08A61K38/21
Inventor 陈玥琦董世武许建中罗飞王一然
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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