Chiral polymer microsphere with porous structure and preparation method thereof

一种多孔结构、聚合物的技术，应用在分离方法、化学仪器和方法、非线性光学等方向，能够解决手性分离承载能力弱、手性点分布不均匀等问题，达到增加手性作用点、提高效果的效果

Active Publication Date: 2020-04-07
JIANGSU JICUI INTELLIGENT LCD TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a chiral stationary phase, polymer microspheres can only construct a chiral environment on the surface of polymer microspheres by bonding chiral groups, chiral filling or chiral coating, etc., which also have different chiral point distributions. Disadvantages of homogeneity, chiral separation and weak carrying capacity

Method used

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  • Chiral polymer microsphere with porous structure and preparation method thereof
  • Chiral polymer microsphere with porous structure and preparation method thereof
  • Chiral polymer microsphere with porous structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Prepare the liquid crystal mixture containing 3g reactive liquid crystal RM257, 6.9g non-reactive liquid crystal E7, 0.1g chiral additive and 0.1g photoinitiator DMPAP (reactive liquid crystal accounts for the percentage of liquid crystal mixture is 29.7%), it according to above The steps are to make polymer microspheres, wherein the micropore diameter of the SPG membrane is 10 microns, the continuous phase is water, and the mass percent concentration of surfactant PVA in water is 3.0%. The chiral additives are R5011 and S5011, respectively, wherein R5011 and S5011 have the same molecular structure but opposite optical activities. like image 3 As shown, the average particle size of the two kinds of polymer microspheres after swelling in ethanol is about 40 microns. At the same time, because the concentric shells of the prepared polymer microspheres are distributed along the radial direction, they have ray-type optical anisotropy (Maltese black cross), and their layere...

Embodiment 2

[0055] Prepare the liquid crystal mixture containing 3g reactive liquid crystal RM257, 6.67g non-reactive liquid crystal E7, 0.33g chiral additive CB15 and 0.1g photoinitiator DMPAP (reactive liquid crystal accounts for 29.7% of liquid crystal mixture), and it is according to the above The steps are to make polymer microspheres, wherein the micropore diameter of the SPG membrane is 10 microns, the continuous phase is water, and the mass percent concentration of surfactant PVA in water is 3.3%. The average particle diameter of prepared chiral polymer microspheres after swelling in ethanol is about 40 microns, micrograph ( Figure 5 (b)) and circular dichroism ( Figure 6 ) also shows that it has a concentric shell structure and dextrorotatory optical activity. At the same time, if Figure 7 As shown, the external SEM image of chiral polymer microspheres shows that it has a porous structure, while its internal SEM image further shows that it has a layered internal structure. ...

Embodiment 3

[0058] Prepare the liquid crystal mixture containing 3g reactive liquid crystal RM257, 6.9g non-reactive liquid crystal E7, 0.1g chiral additive CB15 and 0.1g photoinitiator DMPAP (reactive liquid crystal accounts for the percentage of liquid crystal mixture is 29.7%), it according to above The steps are to make polymer microspheres, wherein the micropore diameter of the SPG membrane is 10 microns, the continuous phase is water, and the mass percent concentration of surfactant PVA in water is 3.0%. The average particle diameter of the prepared chiral polymer microspheres after swelling in ethanol is about 40 microns. Since it uses the same chiral additive as in Example 2, the optical activity of the prepared chiral polymer microspheres is also dextrorotatory. The prepared chiral polymer microspheres were dispersed in deionized water, ethanol and tetrahydrofuran, respectively, Figure 8 It is shown that in different solvents, the chiral polymer microspheres have different swel...

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Abstract

The invention discloses a chiral polymer microsphere with a porous structure. The chiral polymer microsphere is composed of a concentric multilayer shell structure, wherein a spiral conformation is formed among layers of the multilayer shell structure; and the chiral polymer microsphere has optical activity. The invention also discloses a method for preparing the chiral polymer microsphere with the porous structure. The method comprises the following steps of: forming a uniform liquid crystal mixture which comprises reactive liquid crystals, non-reactive liquid crystals, a chiral additive anda polymerization initiator; emulsifying the liquid crystal mixture to form liquid crystal micro-droplets, and dispersing the liquid crystal micro-droplets in a continuous phase; polymerizing the reactive liquid crystals in the liquid crystal micro-droplets to form an intermediate microsphere; and removing the unpolymerized non-reactive liquid crystals and the unpolymerized chiral additive from theintermediate microsphere to form the chiral polymer microsphere. The chiral polymer microsphere disclosed by the invention has a porous structure and a characteristic of being swellable in a solvent,and can be used as a stationary phase for chiral chromatographic separation to improve chiral separation effect.

Description

technical field [0001] The invention relates to the field of polymer microspheres, in particular to chiral polymer microspheres with a porous structure and a preparation method thereof. Background technique [0002] Chirality is an important feature of nature. With the development of life sciences, the demand for optically pure substances is also increasing, and chiral separation has attracted more and more attention. With the rapid development of the field of chiral separation and analysis, higher requirements are put forward for the chiral recognition efficiency and resolution range of chiral materials. One of the urgent problems to be solved in this field. At present, the commonly used method for chiral separation is mainly chiral chromatography. By introducing a chiral environment into the chromatographic column, the adsorption force of optical isomers to the chromatographic column is different, and the purpose of separating optical isomers is finally achieved. Most of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F122/20C08J9/26B01J20/29B01D15/38
CPCC08F122/20C08J9/26B01J20/29B01D15/3833C08J2201/0424C08J2201/0422C09K19/52C08J2201/042C09K2019/122C09K2019/0448C09K19/586G02F1/133531C09K19/12C09K19/20C09K19/56C09K2019/2078C09K2019/525
Inventor 李昂陆嘉伟N·L·阿伯特
Owner JIANGSU JICUI INTELLIGENT LCD TECH CO LTD
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