Chiral polymer microsphere with porous structure and preparation method thereof

Abstract

The invention discloses a chiral polymer microsphere with a porous structure. The chiral polymer microsphere is composed of a concentric multilayer shell structure, wherein a spiral conformation is formed among layers of the multilayer shell structure; and the chiral polymer microsphere has optical activity. The invention also discloses a method for preparing the chiral polymer microsphere with the porous structure. The method comprises the following steps of: forming a uniform liquid crystal mixture which comprises reactive liquid crystals, non-reactive liquid crystals, a chiral additive anda polymerization initiator; emulsifying the liquid crystal mixture to form liquid crystal micro-droplets, and dispersing the liquid crystal micro-droplets in a continuous phase; polymerizing the reactive liquid crystals in the liquid crystal micro-droplets to form an intermediate microsphere; and removing the unpolymerized non-reactive liquid crystals and the unpolymerized chiral additive from theintermediate microsphere to form the chiral polymer microsphere. The chiral polymer microsphere disclosed by the invention has a porous structure and a characteristic of being swellable in a solvent,and can be used as a stationary phase for chiral chromatographic separation to improve chiral separation effect.

Description

technical field

[0001] The invention relates to the field of polymer microspheres, in particular to chiral polymer microspheres with a porous structure and a preparation method thereof. Background technique

[0002] Chirality is an important feature of nature. With the development of life sciences, the demand for optically pure substances is also increasing, and chiral separation has attracted more and more attention. With the rapid development of the field of chiral separation and analysis, higher requirements are put forward for the chiral recognition efficiency and resolution range of chiral materials. One of the urgent problems to be solved in this field. At present, the commonly used method for chiral separation is mainly chiral chromatography. By introducing a chiral environment into the chromatographic column, the adsorption force of optical isomers to the chromatographic column is different, and the purpose of separating optical isomers is finally achieved. Most of...

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