Drug-loaded microspheres, anti-tumor drug and preparation method

Abstract

The invention discloses drug-loaded microspheres, an anti-tumor drug and a preparation method, and relates to the technical field of tumor treatment. The drug-loaded microspheres comprise a loading matrix and an active factor, and the active factor is adsorbed on the loading matrix; wherein the active factor comprises any one or a combination of a chemotactic factor and a cytokine. The drug-loadedmicrospheres can chemotactic the transfer of tumor cells and immune effector cells through loading the loading matrix with the chemotactic factor, promote immune effector cells to kill tumor cells ina targeted manner; and the loading matrix loaded cytokine can promote the immune effector cells to migrate into tumors and promote the proliferation or survival of the immune effector cells, therebyrealizing tumor immunotherapy. The preparation method of the drug-loaded microspheres is simple and easy to popularize and apply. The anti-tumor drug can be prepared from the drug-loaded microspheresand act on tumor cells in a targeting manner.

Description

technical field [0001] The invention relates to the technical field of tumor treatment, in particular to a drug-loaded microsphere, an antitumor drug and a preparation method. Background technique [0002] Immunotherapy is the most promising tumor treatment strategy for clinical application. The basic principle of tumor immunotherapy is to control tumors by enhancing the function of autoimmune effector cells or adopting anti-tumor active cells through biological methods. For solid tumors, an important part of the efficacy of tumor immunotherapy is the migration of immune effector cells into the tumor to achieve direct contact with tumor cells, thereby killing tumor cells. [0003] Inside the tumor, tumor cells and stromal cells can secrete a variety of chemokines, but the function of most chemokines is to promote the migration of immunosuppressive cells into the tumor, while few chemokines can promote the migration of immune effector cells, leading to the killing of tumor c...

AI Technical Summary

Problems solved by technology

[0003] Inside the tumor, tumor cells and stromal cells can secrete a variety of chemokines, but the function of most chemokines is to promote the migration of immunosuppressive cells into the tumor, while few chemokines can promote the migration of immune effector cells, leading to the killing of tumor cells. Tumor-killing immune effector cells cannot effectively reach the inside of the tumor, and tumor immunotherapy is generally less effective against solid tumors

In addition, the efficiency of existing loaded chemotherapy drugs is low, and the existing tumor immunotherapy cannot improve the tumor immunosuppressive microenvironment, and cannot reverse tumor immune escape

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