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Composition comprising mixture of benzodioxolane derivatives and application of composition

A technology of benzodioxolane and dioxolane, applied in medical preparations containing active ingredients, medical raw materials derived from ferns/filamentous plants, plant raw materials, etc., can solve the problems that need to be solved issues such as further improvement

Inactive Publication Date: 2020-04-28
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as Jiaofeng, Liuerbell, Tengnoginseng, Guanzhong, Jinxiancao, Cyclopedia, Babaili, and Punchstone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved

Method used

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  • Composition comprising mixture of benzodioxolane derivatives and application of composition
  • Composition comprising mixture of benzodioxolane derivatives and application of composition
  • Composition comprising mixture of benzodioxolane derivatives and application of composition

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Experimental program
Comparison scheme
Effect test

preparation example 1

[0074] The preparation of preparation example 1 plant extract

[0075] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, take 50g of plant dry powder, add different organic solvents and carry out ultrasonic extraction (as shown in Table 1), each 60min, repeat extraction 3 times. After filtration, it was concentrated to dryness and stored in a refrigerator at 4°C until use.

[0076] Table 1 Organic solvents for ultrasonic extraction of different plant extracts

[0077] plant material Extract number solvent for extraction red yaozi PE1 ethanol Guan Zhong PE2 ethyl acetate broken bone PE3 acetone Six ear bells PE4 acetone one-legged PE5 ethanol piercing broken stone PE6 n-heptane

Embodiment 1

[0147] Embodiment 1 Preparation of solid formulation containing the composition of benzodioxolane derivative mixture

[0148] prescription

[0149]

[0150]

[0151] Preparation

[0152] The active ingredients and auxiliary materials of the prescribed amount are all passed through a 100-mesh sieve. Get the active ingredient, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; get the hypromellose of the prescription amount, and prepare a solution with a concentration of 10% based on hypromellose, add lactic acid Adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to granulate, add the prescribed amount of micropowder silica gel and magnesium stearate, mix and mix, and fill into capsules each weighing about 500 mg;

[0153] The active ingredients and auxiliary materials of the prescribed amount are all passed through a...

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Abstract

The invention provides a composition comprising a mixture of a first benzodioxolane derivative and a second benzodioxolane derivative which are different from each other, wherein the benzodioxolane derivatives are specifically defined in the specification. The mixture provided by the invention can synergistically increase the inhibition effect of extracts of plants such as girald pteroxygonum roots and the like on bacteria such as Kocuria kristinae and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing a mixture of benzodioxolane derivatives and its application. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN109045300A discloses nanoparticles containing benzodioxolane derivatives with the structure shown in formula I and having certain antibacterial activity; [0004] [0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K31/437A61K31/4985A61P31/04
CPCA61K31/437A61K31/4985A61K36/12A61K36/185A61K36/28A61K36/60A61K36/63A61K36/704A61P31/04A61K2300/00Y02A50/30
Inventor 向飞张斌
Owner 黄泳华
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