Microneedle with convex table structure, and preparation method for microneedle

Abstract

The invention discloses a microneedle with single or a plurality of convex table structures, and a preparation method for the microneedle. The preparation method comprises the following steps of purifying a monocrystalline silicon substrate, preparing a monocrystalline silicon substrate protection film, carrying out silicon substrate protection film imaging, preparing a convex table and a microneedle body, and carrying out postprocessing. The invention has an effect that the nanometer monocrystalline silicon microneedle with the convex table structure is designed, the monocrystalline silicon microneedle can penetrate through the cuticle of skin without touching the corium layer and the subcutaneous nervous system, and a channel is created for the percutaneous entry of media, including biological medicines and the like, under a situation that skin pain and irritation is not caused. Meanwhile, due to the existence of the convex table structure, a percutaneous introduction channel is effectively expanded, and a biological medicine medium storage space is enlarged so as to be more favorable for introducing media, including biological medicines and the like, into the skin to be absorbed.

Description

technical field [0001] The invention relates to the field of transdermal drug release devices, in particular to a nanometer microneedle with a boss structure and a preparation method thereof. Background technique [0002] Transdermal administration is usually based on subcutaneous injection, which has disadvantages such as pain, professional operation, infection or tissue damage at the injection site. And existing transdermal drug delivery, as medicine coating, plaster patch etc., although use painless, convenient, can because the barrier that skin stratum corneum forms, has blocked the absorption of more than 95% medicine and nutrient, especially It is more difficult for macromolecular drugs to break through the stratum corneum barrier. [0003] Microneedle is a promising transdermal drug delivery technology. It is a new type of physical penetration enhancement method, which can easily penetrate the stratum corneum of the skin without touching the dermis, subcutaneous nerv...

AI Technical Summary

Problems solved by technology

[0004] Most of the existing nano-microneedles are monocrystalline silicon nano-microneedles, most of which are conical structures, and the needle tip size can reach the nanometer level, which can form nano-scale tiny channels in the stratum corneum of the skin, allowing drugs or nutrients to pass through the stratum corneum of the skin Layer barrier, directly acts on the dermis layer of the skin, but because the incision channel is too small, the absorption of drugs and nutrients is limited

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