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Traditional Chinese medicine composition capable of protecting livers and reducing lipid and preparation method and application of traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of liver-protecting and lipid-lowering traditional Chinese medicine composition and its preparation, can solve the problems of steatohepatitis treatment and medication

Active Publication Date: 2020-05-22
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, Western medicine treatment drugs are commonly used in clinical treatment of simple fatty liver, such as Hugan Tablets, Shell Fat Capsules, Qianggan Capsules, and silymarin, but there is no drug for the treatment of steatohepatitis

Method used

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  • Traditional Chinese medicine composition capable of protecting livers and reducing lipid and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of protecting livers and reducing lipid and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of protecting livers and reducing lipid and preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 Chinese medicine compound granule

[0036] Prescription: 20 parts of weeping grass, 10 parts of seaweed, 20 parts of calcined oyster, 10 parts of hawthorn, 20 parts of wine squirrel, 10 parts of vinegar schisandra, 15 parts of knotweed.

[0037] The preparation method of this Chinese medicine composition granule can be selected from any one of the following methods:

[0038] a. Take weeping grass, seaweed, calcined oyster, hawthorn, knotweed, wine scorpion grass, vinegar schisandra, add 10 times the amount of water to reflux and extract twice, each time for 1 to 2 hours, combine the extracts, concentrate under reduced pressure to relative The extract with a density of 1.10-1.40 is dried under reduced pressure and pulverized to obtain a traditional Chinese medicine composition 1, which is added with lactose, mixed evenly, and granulated to obtain granule 1 by dry granulation.

[0039] b. (1) Add 10 times the amount of water to extract the weeping grass, sea...

Embodiment 2

[0043] Embodiment 2 Chinese medicine compound capsule

[0044] Prescription: 30 parts of weeping grass, 10 parts of seaweed, 30 parts of calcined oyster, 20 parts of hawthorn, 30 parts of knotweed, 40 parts of wine weasel, 15 parts of vinegar schisandra.

[0045] The preparation method of this Chinese medicine composition capsule can be selected from any one of the following methods as follows:

[0046] a. Take weeping grass, seaweed, calcined oyster, hawthorn, knotweed, wine weasel, vinegar schisandra, add 8 times the amount of water to reflux and extract 3 times, each time for 1 to 2 hours, combine the extracts, concentrate under reduced pressure to relative The extract with a density of 1.00-1.30 is spray-dried and granulated to make capsules.

[0047] b. (1) Add 8 times the amount of water to extract 3 times, each time for 1 to 2 hours, combine the extracts, concentrate under reduced pressure to a water extraction extract with a relative density of 1.00 to 1.30;

[0048]...

Embodiment 3

[0051] Embodiment 3 Chinese medicine compound tablet

[0052] Prescription: 80 parts of weeping grass, 40 parts of seaweed, 50 parts of calcined oyster, 30 parts of hawthorn, 50 parts of knotweed, 40 parts of wine weasel, 20 parts of vinegar schisandra.

[0053] The preparation method of this Chinese medicine composition tablet can be selected from any one of following methods:

[0054] a. Take weeping grass, seaweed, calcined oyster, hawthorn, knotweed, wine scorpion grass, vinegar schisandra, add 12 times the amount of water to reflux and extract twice, each time for 1 to 2 hours, combine the extracts, concentrate under reduced pressure to relative The extract with a density of 1.00 to 1.30 is dried in a vacuum belt and crushed to obtain an intermediate composition 1, which is made into a tablet 1 by adding auxiliary materials such as microcrystalline cellulose.

[0055] b. (1) Add 8 times the amount of water to extract 3 times, each time for 1 to 2 hours, combine the extra...

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Abstract

The invention provides a traditional Chinese medicine composition capable of protecting livers and reducing lipid. The traditional Chinese medicine composition is characterized by comprising, in partsby weight, 1-100 parts of herba sedi, 1-100 parts of seaweeds, 1-100 parts of calcined oyster shells, 1-100 parts of hawthorns, 1-100 parts of alcohol-treated Herba Siegesbeckiae, 1-100 parts of vinegar-added Schisandra chinensis and 1-100 parts of rhizoma polygoni cuspidati. Through the composition, the content of triglyceride, total cholesterol and low-density lipoprotein-cholesterol (P<0.05) in liver-disease model rats can be reduced significantly, the level of high-density lipoprotein-cholesterol (P<0.05) is increased significantly, and it is shown that the prepared composition has the effect of treating non-alcoholic steatohepatitis. Moreover, it is also confirmed through experiments that the traditional Chinese medicine composition is capable of reducing the activity of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease in serum and the secretion amount of IL-6 in the liver tissue of the model rats significantly, and it is also shown that the traditional Chinesemedicine composition has a significant protective effect on rat liver injury caused by CC14.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for protecting the liver and lowering fat, as well as its preparation method and application. Background technique [0002] Steatohepatitis is a non-infectious inflammation of the liver caused by fatty liver disease becoming more and more serious, and the invasion of fat cells affects liver function. [0003] There is no name for "steatohepatitis" in traditional Chinese medicine, and related theories of Chinese medicine are commonly found in the understanding of diseases such as "accumulated syndrome", "fullness", "hypochondriac pain", "fat gas", and "phlegm dampness". Ancient and modern physicians have different understandings of its etiology and pathogenesis, and there is no unity. In the 2002 edition of "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine", simple fatty liver is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K36/79A61P1/16A61K35/618
CPCA61K36/41A61K36/02A61K35/618A61K36/734A61K36/28A61K36/79A61K36/57A61K36/704A61P1/16A61K2236/331A61K2236/39A61K2236/333A61K2236/51A61K2236/53A61K2300/00
Inventor 肖伟韦迎春季光张磊李芳闫明贾银芝吕耀中徐臻吴云吴伟王振中
Owner JIANGSU KANION PHARMA CO LTD
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