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Film-forming povidone-iodine solution as well as preparation method and application thereof

A povidone-iodine and film-forming technology, which is applied in the field of film-forming povidone-iodine solution and its preparation, can solve the problems of unfulfilled use requirements, poor fluidity, cumbersome production process, etc., and achieve the prevention of persistent infection, cutting off The infection route and the effect of simple operation of the process steps

Pending Publication Date: 2020-06-12
HENAN KANGXING PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Povidone-iodine solution in the prior art has poor fluidity in a low temperature environment, cannot meet the use requirements, and the production process is relatively cumbersome

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Film-forming povidone-iodine solution, every 1L of this povidone-iodine solution contains the following components by weight: 45g polyvinyl alcohol 17-88, 11g povidone-iodine, 3g povidone K30, 0.5 g potassium iodate, 4 g sodium dihydrogen phosphate, 0.7 g disodium hydrogen phosphate, 157.8 g ethanol, 151.32 g glycerol.

[0035] The preparation method of film-forming povidone-iodine solution comprises the following steps:

[0036] (1) Take 45g of polyvinyl alcohol 17-88, add 250ml of purified water, stir until completely dissolved, and let it stand overnight to obtain solution 1;

[0037] (2) Get the qualified 3g povidone K30, add 200ml purified water, fully stir until dissolving;

[0038] (3) Take by weighing 11g povidone-iodine, add in the solution of step (2);

[0039] (4) Use 1mol / L sodium hydroxide solution to adjust the pH of the solution obtained in step (3) to 5.0 ± 0.2;

[0040] (5) Weigh 0.5g potassium iodate, 4g sodium dihydrogen phosphate, 0.7g disodium hy...

Embodiment 2

[0044] Film-forming povidone-iodine solution, every 1L of this povidone-iodine solution contains the following components by weight: 50g polyvinyl alcohol 17-88, 11g povidone-iodine, 3g povidone K30, 0.5 g potassium iodate, 4 g sodium dihydrogen phosphate, 0.7 g disodium hydrogen phosphate, 157.8 g ethanol, 151.32 g glycerol.

[0045] The preparation method of film-forming povidone-iodine solution comprises the following steps:

[0046](1) Take 50g of polyvinyl alcohol 17-88, add 250ml of purified water, stir until completely dissolved, let stand overnight, and obtain solution 1;

[0047] (2) Get the qualified 3g povidone K30, add 200ml purified water, fully stir until dissolving;

[0048] (3) Take by weighing 11g povidone-iodine, add in the solution of step (2);

[0049] (4) Use 1mol / L sodium hydroxide solution to adjust the pH of the solution obtained in step (3) to 5.0 ± 0.2;

[0050] (5) Weigh 0.5g potassium iodate, 4g sodium dihydrogen phosphate, 0.7g disodium hydrogen...

Embodiment 3

[0054] Film-forming povidone-iodine solution, every 1L of the povidone-iodine solution contains the following components by weight: 55g polyvinyl alcohol 17-88, 11g povidone-iodine, 3g povidone K30, 0.5 g potassium iodate, 4 g sodium dihydrogen phosphate, 0.7 g disodium hydrogen phosphate, 157.8 g ethanol, 151.32 g glycerol.

[0055] The preparation method of film-forming povidone-iodine solution comprises the following steps:

[0056] (1) Take 55g of polyvinyl alcohol 17-88, add 250ml of purified water, stir until completely dissolved, and let stand overnight to obtain solution 1;

[0057] (2) Get the qualified 3g povidone K30, add 200ml purified water, fully stir until dissolving;

[0058] (3) Take by weighing 11g povidone-iodine, add in the solution of step (2);

[0059] (4) Use 1mol / L sodium hydroxide solution to adjust the pH of the solution obtained in step (3) to 5.0 ± 0.2;

[0060] (5) Weigh 0.5g potassium iodate, 4g sodium dihydrogen phosphate, 0.7g disodium hydrog...

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Abstract

The invention discloses a film-forming povidone-iodine solution as well as a preparation method and an application thereof. Every 1L of povidone iodine comprises the following components in parts by weight: 45-60 parts of polyvinyl alcohol, 10-110 parts of povidone iodine, 1-3 parts of povidone K30, 0.1-5 parts of an effective iodine stabilizer, 4.7 parts of a pH stabilizer and 200-400 parts of amoisturizing and skin-moistening anti-freezing agent. The solution is simple in process and convenient to operate; the product obtained by the invention has good adhesiveness, stability and bactericidal power; the effects of disinfection and sterilization are guaranteed, meanwhile, the effects on the skin surface are mild and non-irritant, and the effects of effectively keeping the skin moist andelastically moistening the skin can be achieved; the mobility is kept in a low-temperature environment, the use is convenient, and the disinfection and sterilization requirements in the low-temperature environment are met.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a film-forming povidone-iodine solution and a preparation method and application thereof. Background technique [0002] Povidone-iodine (PVP-I) is a topical disinfectant and preservative formed by the complexation of iodine and polymer compound povidone (PVP). Povidone-iodine is povidone iodine disinfectant, which is a broad-spectrum powerful bactericidal disinfectant, which has a strong killing effect on viruses, bacteria, fungi and mold spores. PVP is a non-ionic surfactant hydrophilic polymer, which has no antibacterial effect itself, but can improve the solubility of iodine. During the production process, PVP forms a micro-cavity carrier, and complexes iodide ions in the cavity of the microcapsule to form PVP-I. In the aqueous solution state, due to its affinity to the cell membrane, iodine can be directly introduced to the surface of bacterial cells, which is ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/10A61K47/02A61K33/18A61K31/79A61P17/02A61P31/02
CPCA61K9/7015A61K47/32A61K47/10A61K47/02A61K33/18A61K31/79A61P17/02A61P31/02
Inventor 王林马仲彬张国祖王兴涛杨帅张晓杰
Owner HENAN KANGXING PHARMA
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