The application discloses a multifunctional
antibacterial coating bone implant device based on a selective vacuum
perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a
titanium alloy base; 2) performing
anodic oxidation treatment on the pretreated
titanium alloy base to construct a
nanotube structure on the surface of the
titanium alloy base; 3) selectively
coating the treated
titanium alloy base with a hydrogel
adhesive, then immersing the
titanium alloy base in a povidone
iodine mixed solution to perform vacuum
perfusion, and performing post-treatment, then again performing selective
coating, immersing the
titanium alloy base in a solution containing a
bone growth promoting factor to perform vacuum
perfusion, and performing post-treatment, then again performing selective
coating, immersing the titanium alloy base in a solution containing a
blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-
drying. The
bone implant device has antibacterial,
bone growth promoting and
blood vessel growth promoting functions, and can greatly improve the
curative effect on
bone fracture symptoms accompanied by infection.